This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Tofacitinib, an oral janus kinase inhibitor, in active ulcerative colitis. N Engl J Med 2012; 367: 616-624.

Published: 11th February 2013

Authors: Sandborn WJ, Ghosh S, Panes J, Vranic I, Su C, Rousell S et al. et al.

Conclusion

This was a dose ranging study over eight weeks in 194 adults with moderate to severe colitis. A clinical response was more likely in patients who had the highest dose of the drug (15mg): 78 per cent versus 42 per cent with placebo; P<0.001.

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