Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 120-127.

Authors: Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW et al.

Scientific Surgery

Efficacy and safety of ursodeoxycholic acid for the prevention of gallstone formation after gastrectomy in patients with gastric cancer. The PEGASUS-D randomized clinical trial. JAMA Surg 2020; 155: 703-711.

Authors: Lee SH, Jang DK, Yoo M-W, Hwang S-H, Ryu S-Y, Kwon OK et al.

Scientific Surgery

Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer. A randomized clinical trial. JAMA Surg 2020; 155: 300-311.

Authors: Chen Q-Y, Xie J-W, Zhong Q, Wang J-B, Lin J-X, Lu J et al.

Scientific Surgery

Effect of perioperative oral nutritional supplementation in malnourished patients who undergo gastrectomy: a prospective randomized trial. Surgery 2018; 164: 1263-1270.

Authors: Kong S-H, Lee H-J, Na J-R, Kim WG, Han D-S, Park S-H et al.

Scientific Surgery

Helicobacter pylori therapy for the prevention of metachronous gastric cancer. N Engl J Med 2018; 378: 1085-1095.

Authors: Choi IJ, Kook M-C, Kim Y-I, Cho S-J, Lee JY, Kim CG et al.

Scientific Surgery

Adjuvant chemoradiotherapy with epirubicin, cisplatin, and fluorouracil compared with adjuvant chemoradiotherapy with fluorouracil and leucovorin after curative resection of gastric cancer: results from CALGB 80101 (Alliance). J Clin Oncol 2017; 35: 3671-3677.

Authors: Fuchs CS, Niedzwiecki D, Mamon HJ, Tepper JE, Xing Y, Swanson RS et al.

Scientific Surgery

Phase III trial to compare adjuvant chemotherapy with capecitabine and cisplatin versus concurrent chemoradiotherapy in gastric cancer: final report of the adjuvant chemoradiotherapy in stomach tumors trial, including survival and subset analyses. J Clin Oncol 2015; 33: 3130-3136.

Authors: Park SH, Sohn TS, Lee J, Lim DH, Hong ME, Kim K-M et al. et al.

Scientific Surgery

Effect of daikenchuto, a traditional Japanese herbal medicine, after total gastrectomy for gastric cancer: a multicenter, randomized, double-blind, placebo-controlled, phase II trial. J Am Coll Surg 2015; 221: 571–578.

Authors: Yoshkawa K, Shimada M, Wakabayashi G, Ishida K, Kaiho T, Kitagawa Y et al. et al.

Scientific Surgery

Preoperative vs postoperative eradication of Helicobacter pylori in 150 patients with gastric cancer: a randomized controlled trial. J Am Coll Surg 2015; 221: 273–279.

Authors: Honda M, Hiki N, Nunobe S, Ohashi M, Kumagai K, Hashimoto Y et al. et al.

Scientific Surgery

Clinical effectiveness of neoadjuvant chemotherapy in advanced gastric cancer: an updated meta-analysis of randomized controlled trials. Eur J Surg Oncol 2014; 40: 1321-1330.

Authors: Xiong B, Ma L, Cheng Y, Zhang C

Scientific Surgery

Intensive versus conventional insulin therapy in type 2 diabetes patients undergoing D2 gastrectomy for gastric cancer: a randomised controlled trial. World J Surg 2011; 35: 85-92.

Authors: Cao S-G, Ren J-A, Shen B, Chen D, Zhou Y-B, Li J-S. et al.

Scientific Surgery

Neoadjuvant chemotherapy compared with surgery alone for locally advanced cancer of the stomach and cardia: European Organisation for Research and Treatment for Cancer randomized trial 40954. J Clin Oncol 2010; 29: 5210–5218.

Authors: Schuhmacher C, Gretschel S, Lordick F, Reichardt P, Hohenberger W, Elsenberger CF et al. et al.

Scientific Surgery

Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial Lancet 2008; 372: 392¿397

Authors: Fukase K, Kato M, Kikuchi S, Inoue K, Uemura N, Okamoto S et al et al.

Scientific Surgery

Adjuvant chemotherapy in completely resected gastric cancer: a randomized phase III trial conducted by GOIRC. J Natl Cancer Inst 2008; 100: 388-398.

Authors: Di Costanzo F, Gasperoni S, Manzione L, Bisagni G, Labianca R, Bravi S et al.

Scientific Surgery

Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med 2007; 357: 1810-1820.

Authors: Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A et al.

Scientific Surgery

Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial. J Natl Cancer Inst 2007; 99: 601-607.

Authors: Cascinu S, Labianca R, Barone C, Santoro A, Carnaghi C, Cassano A et al.

Scientific Surgery

Chemoprevention of precancerous gastric lesions with antioxidant vitamin supplementation: a randomized trial in a high-risk population. J Natl Cancer Inst 2007; 99: 137-146.

Authors: Plummer M, Vivas J, Lopez G, Bravo JC, Peraza S, Carillo E et al.

Scientific Surgery

Peroperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006; 24: 4620-4625.

Authors: Gerard JP, Conroy T, Bonnetain F, Bouche O, Chapet O, Closon-Dejardin MT et al.

Scientific Surgery

Randomised double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006; 14: 974¿983.

Authors: You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS et al.

Scientific Surgery

Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006; 355: 11-20.

Authors: Cunningham D, Allum WH, Stenning SP, Thompson JN, van de Velde CJH, Nicolson M et al.

Scientific Surgery

Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006; 24: 2903-2909.

Authors: Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig E. et al.

Scientific Surgery

Randomized trial of adjuvant chemotherapy after curative resection for gastric cancer. Am J Surg 2004; 187: 440-445.

Authors: Chipponi J, Huguier M, Pezet D, Basso N, Hay J-M, Quandalle P et al.

Scientific Surgery

Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomcyin in patients with unresectable, advanced gastric cancer: The Japan Clinical J Clin Oncol 2003; 21: 54-9.

Authors: Ohtsu A, Shimada Y, Shirao K, Boku N, Hyodo I, Saito H et al. et al.

Scientific Surgery

Neoadjuvant or adjuvant therapy for respectable gastric cancer? A practice guideline Can J Surg 2002; 45: 438-46

Authors: Earle CC, Maroun J, Zuraw L and the Cancer Care Ontario Practice Guidelines Initiative Gastrointestinal Cancer Disease Site Group

Scientific Surgery

Concentrated preoperative radiotherapy for resectable gastric cancer: 20- years follow-up of a randomized trial. J Surg Oncol 2002; 80: 72-8.

Authors: Skoropad V, Berdov B, Zagrebin V.

Scientific Surgery

Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345: 725- 730.

Authors: Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN et al.

Scientific Surgery

Indications for early postoperative intraperitoneal chemotherapy of advanced gastric cancer: a prospective randomized trial. World J Surg 2001; 25: 985-90

Authors: Yu W, Whang I, Chung HY, Averbach A, Sugarbaker PH.

Scientific Surgery

A prospective randomized trial of pre-operative and intra-operative radiotherapy versus surgery alone in resectable gastric cancer. Eur J Surg Oncol 2000; 26: 773-9.

Authors: Skoropad VY, Berdov BA, Mardynski YS, Titova LN.

Scientific Surgery

Adjuvant therapy for gastric carcinoma patients in the past 15 years: a review of western and oriental trials. Cancer 1999; 86: 1657-68.

Authors: Shimada K, Ajani JA.

Scientific Surgery

Adjuvant mitomycin and fluorouracil followed by oral uracil plus tegafur in serosa negative gastric cancer: a randomised trial. Lancet 1999; 354: 273-7.

Authors: Nakajima T, Nashimoto A, Kitamura M, Kito T, Iwanaga T, Okabayashi K et al and the Gastric Cancer Surgical Study Group. et al.

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