Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADE-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol 2020; 5: 343-351.

Authors: Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C et al.

Scientific Surgery

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.

Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.

Scientific Surgery

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Cornish AJ, Law PJ, Tomofeeva M, Palin K, Farrington SM, Palles C et al.

Scientific Surgery

Efficacy and safety of sodium picosulfate/magnesium citrate for bowel preparation in a physically disabled outpatient population: a randomized, endoscopist-blinded comparison with ascorbic acid-enriched polyethylene glycol solution plus bisacodyl (The PICO-MOVI Study). Dis Colon Rectum 2018; 61: 239-249.

Authors: Mathus-Vliegen E, van der Vliet K, Wignand-van der Storm IJ, Stadwijk J

Scientific Surgery

Comparative evaluation of the efficacy of polyethylene glycol with ascorbic acid and an oral sulfate solution in a split method for bowel preparation: a randomized, multicenter phase III clinical trial. Dis Colon Rectum 2017; 60: 426-432.

Authors: Bun K, Lee SD, Han KS, Kim BC, Youk E-G, Nam MJ et al.

Scientific Surgery

Split-dose preparation for colonoscopy increases adenoma detection rate: a randomised controlled trial in an organised screening programme. Gut 2017; 66: 270-277.

Authors: Paggi S, Hassan C, Senore C, Fasoli R, Anderloni A, Buffoli F et al.

Scientific Surgery

Celecoxib for the prevention of colorectal adenomas: results of a suspended randomized controlled trial. J Natl Cancer Inst 2016; 108: djw151.

Authors: Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F et al.

Scientific Surgery

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia. BMJ 2016; 355: i6188.

Authors: Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ et al.

Scientific Surgery

Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial. Gut 2015; 64: 1569-1577.

Authors: Kaltenbach T, Rastogi A, Rouse RV, McQuaid KR, Sato T, Bansal A et al. et al.

Scientific Surgery

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut 2015; 64: 1419-1425.

Authors: Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y et al. et al.

Scientific Surgery

A trial of calcium and vitamin D for the prevention of colorectal adenomas. N Engl J Med 2015; 373: 1519-1530.

Authors: Baron JA, Barry EL, Mott LA, Rees JR, Sandler RS, Snover DC et al. et al.

Scientific Surgery

The preventive effects of low-dose enteric-coated aspirin tablets on the development of colorectal tumours in Asian patients: a randomised trial. Gut 2014; 63: 1755-1759.

Authors: Ishikawa H, Mutoh M, Suzuki S, Tokudome S, Saida Y, Abe T et al. et al.

Scientific Surgery

Randomized clinical trial comparing reduced-volume oral picosulphate and a prepackaged low-residue diet with 4-liter PEG solution for bowel preparation. Dis Colon Rectum 2014; 57: 522-528.

Authors: Kim Ys, Hong CW, Kim BC, Han KS, Park JW, Seong Choi H et al. et al.

Scientific Surgery

Telephone-based re-education on the day before colonoscopy improves the quality of bowel preparation and the polyp detection rate: a prospective colonoscopist-blinded, randomised controlled study. Gut 2014; 63: 125-130.

Authors: Liu X, Luo H, Zhang L, Leung FW, Liu Z, Wang X et al. et al.

Scientific Surgery

Computed tomographic colonography versus colonoscopy for investigation of patients with symptoms suggestive of colorectal cancer (SIGGAR): a multicentre randomised trial. Lancet 2012; 381: 1194–1202.

Authors: Atkin W, Dadswell E, Wooldrage K, Kralj-Hans I, von Wagner C, Edwards R et al. et al.

Scientific Surgery

Computed tomographic colonography versus barium enema for diagnosis of colorectal cancer or large polyps in symptomatic patients (SIGGAR): a multicentre randomised trial. Lancet 2012; 381: 1185–1193.

Authors: Halligan S, Wooldrage K, Dadswell E, Kralj-Hans I, von Wagner C, Edwards R et al. et al.

Scientific Surgery

Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut 2012; 61: 255-261.

Authors: Benamouzig R, Uzzan B, Deyra J, Martin A, Girard B, Little J et al. et al.

Scientific Surgery

Higher adenoma detection rates with cap-assisted colonoscopy: a randomised controlled trial. Gut 2012; 61: 402-408.

Authors: Rastogi A, Bansal A, Rao DS, Gupta N, Wani SB, Shipe T et al. et al.

Scientific Surgery

Long term effect of aspirin on colorectal cancer incidence and mortality: 20 year follow-up of five randomised trials. Lancet 2010; 376: 1741-1750.

Authors: Rothwell PM, Wilson M, Elwin C-E, Norving B, Algra A, Warlow CP et al. et al.

Scientific Surgery

Nonsteroidal anti-inflammatory drug use after 3 years of aspirin use and colorectal adenoma risk: observational follow-up of a randomised study J Natl Cancer Inst 2009; 101: 267-276

Authors: Grau MV, Sandler RS, McKeown-Eyssen G, Bresalier RS, Haile RW, Barry EL et al.

Scientific Surgery

Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials J Natl Cancer Inst 2009; 101: 256-266

Authors: Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ et al et al.

Scientific Surgery

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch Syndrome N Engl J Med 2008; 359: 2567¿2578

Authors: Burn J, Bishop T, Mecklin J-P, Macrae F, Moslein G, Olschwang S et al et al.

Scientific Surgery

Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007; 369: 1603-1613.

Authors: Flossmann E, Rothwell PM.

Scientific Surgery

Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 2007; 297: 2351-2359.

Authors: Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS et al.

Scientific Surgery

Systematic review of laparoscopic versus open surgery for colorectal cancer. Br J Surg 2006; 93: 921¿928.

Authors: Reza MM, Blasco JA, Andradas E, Cantero R, Mayol J.

Scientific Surgery

Phase III trial of ursodeoxycholic acid to prevent colorectal adenoma recurrence. J Natl Cancer Inst 2005; 97: 846-853.

Authors: Alberts DS, Martinez ME, Hess LM, Einspahr JG, Green SB, Bhattacharyya AK et al.

Scientific Surgery

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med 2003; 348: 883-890.

Authors: Sandler RS, Halabi S, Baron JA, Budinger S, Paskett E, Keresztes R et al. et al.

Scientific Surgery

A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis. Gut 2002; 50: 857-60.

Authors: Phillips RKS, Wallace MH, Lynch PM, Hawk E, Gordon GB, Saunders BP et al. et al.

Scientific Surgery

Risks, costs and compliance limit colorectal adenoma surveillance: lessons from a randomised trial. Gut 2001; 49: 91-6.

Authors: Lund JN, Schofield JH, Grainge MJ, Smith SJ, Mangham C, Armitage NC et al. et al.

Scientific Surgery

Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. Lancet 2000; 356: 1300-6.

Authors: Bonithon-Kopp C, Kronborg O, Giacosa A, Rdth U, Faivre J for the European Cancer Prevention Organisation Study Group.

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