The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized trial of vonapanitase (PATENCY-1) to promote radiocephalic fistula patency and use for hemodialysis. J Vasc Surg 2019; 69: 507-515

Published: 22nd November 2019

Authors: Bleyer A, Scavo VA, Wilson SE , Browne BJ, Ferris BL, Ozaki CK et al.


Vonapanitase is a recombinant human elastase applied topically after fistula formation; its value in improving patency of dialysis fistulas was studied in 311 patients. Whilst primary patency at 12 months was not improved (42 per cent versus 31 per cent for placebo; P=0.25), secondary patency was better (74 versus 61 per cent, respectively; P=0.045).

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