The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Hypothermic machine perfusion in liver transplantation — a randomized trial. N Engl J Med 2021; 384: 1391-1401.

Published: 1st November 2021

Authors: Van Rijn R, Schurink II, de Vries Y, van den Berg AP, Cerisuelo MC, Murad AD et al.


Use of machine perfusion reduced the rate of allograft dysfunction (26 versus 40 per cent) in this study that included 156 procedures. It also reduced the risk of non-anastomotic biliary stricture: 6 versus 18 per cent, P=0.03.

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