This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
A meta-analysis of the impact of aspirin, clopidogrel, and dual antiplatelet therapy on bleeding complications in noncardiac surgery. Ann Surg 2018; 267: 1-10.
Published: 5th April 2018
Authors: Columbo J, Lambour AJ, Sundling RA, Chauhan NB, Bessen SY, Linshaw D et al.
Conclusion
This meta-analysis of 46 studies included over 30,000 procedures. There was a small but significant increased risk of transfusion versus control for aspirin (relative risk 1.14, 95 per cent confidence interval 1.03 to 1.26, P=0.009) and dual antiplatelet therapy (1.33, 1.15 to 1.55, P=0.001), but no difference in mortality.
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