This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med 2017; 377: 1319-1330.

Published: 28th November 2017

Authors: Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O et al.

Conclusion

Almost 30,000 people with stable vascular disease were included. The primary outcome was a composite: cardiovascular death, stroke or myocardial infarction, which was reached after a mean of 23 months in 4.1 percent on rivaroxaban plus aspirin, and 5.4 per cent on aspirin alone, P<0.001. The combination had more major bleeding events: 3.1 versus 1.9 per cent, P<0.001.

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