This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Stopping vs. continuing aspirin before coronary artery surgery. N Engl J Med 2016; 374: 728-737.

Published: 4th February 2016

Authors: Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T et al.

Conclusion

Some 2100 patients were included; the composite primary outcome included death and thrombotic complications. Rates were similar with aspirin (19.3 per cent) versus no aspirin (20.4 per cent), P=0.55. Haemorrhagic complications were also similar.

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Association of intravenous tranexamic acid with thromboembolic events and mortality. A systematic review, meta-analysis, and meta-regression. JAMASurg 2021; 156: e210884.

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Prophylactic topical tranexamic acid versus placebo in surgical patients. A systematic review and meta-analysis. Ann Surg 2021; 273: 676-683.

Authors: Teoh WY, Tan TG, Ng KT, Ong KX, Chan XL, Hung T et al.

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Meta-analysis, meta-regression, and GRADE assessment of randomized and nonrandomized studies of incisional negative pressure wound therapy versus control dressings for the prevention of postoperative wound complications. Ann Surg 2020; 272: 81-91.

Authors: Zwanenburg P, Tol BT, Obdeijn MC, Lapid O, Gans SL, Boermeester MA et al.

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Incisional surgical site infection after abdominal fascial closure with Triclosan-coated barbed suture vs Triclosan-coated polydioxanone loop suture vs polydioxanone loop suture in emergent abdominal surgery. A randomized clinical trial. J Am Coll Surg 2020; 230: 766-774.

Authors: Ruiz-Tovar J, Llavero C, Jimenez-Fuertes M, Duran M, Perez-Lopez M, Garcia-Marin A et al.

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Effect of cricoid pressure compared with a sham procedure in the rapid sequence induction of anesthesia. The IRIS Randomized Clinical Trial. JAMA Surg 2019; 154: 9-17

Authors: Birenbaum A, Hajage D, Roche S, Ntouba A, Eurin M, Cuvillon P et al.

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Effect of intraoperative high positive end-expiratory pressure (PEEP) with recruitment maneuvers vs low PEEP on postoperative pulmonary complications in obese patients. A randomized clinical trial. JAMA 2019; 321: 2305-2292

Authors: Writing Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of Anaesthesiology

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Prophylactic negative pressure wound therapy in closed abdominal incisions: a meta-analysis of randomised controlled trials. World J Surg 2019; 43: 2779–2788

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Perioperative fluid restriction in abdominal surgery: a systematic review and meta-analysis. World J Surg 2019; 43: 2747-2755

Authors: Yanfei S, Guolong C, Shijin G, Jing Y

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The impact of preoperative immune modulating nutrition on outcomes in patients undergoing surgery for gastrointestinal cancer. A systematic review and meta-analysis. Ann Surg 2019; 270: 247-256

Authors: Adiamah A , Skořepa P, Weimann A , Lobo D

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Negative pressure wound therapy for surgical-site infections. A randomized trial. Ann Surg 2019; 269: 1034-1040.

Authors: Javed A, Teinor J, Wright M, Ding D, Burkhart RA, Hundt J et al.

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Authors: Ichida K, Noda H, Kikugawa R, Hasegawa F, Obitsu T, Ishioka D et al.

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Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial. Lancet 2018; 391: 2325-2334.

Authors: Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM et al.