This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial. Lancet 2017; 390: 469–479.
Published: 30th September 2017
Authors: Rullier E, Rouanet P, Tuech J-J, Valverde A, Lelong B, Rivoire M et al.
Conclusion
Some 148 patients with good response to neoadjuvant chemoradiotherapy were randomized. The trial failed to show superiority of local excision because 26/74 patients in that group went on to have completion total mesorectal excision. The composite outcome that included death, recurrence and morbidity at two years was similar in both groups: odds ratio 1.33, 95 per cent confidence interval 0.62 to 2.86, P=0.43.
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