This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of interval (7 or 11 weeks) between neoadjuvant radiochemotherapy and surgery on complete pathologic response in rectal cancer: a multicenter, randomized, controlled trial. J Clin Oncol 2016; 34: 3773-3780.

Published: 30th March 2017

Authors: Lefevre JH, Mineur L, Kotti S , Rullier E, Rouanet P, de Chaisemartin C et al.

Conclusion

The rate of complete pathological response was similar whether surgery was done after 7 weeks (15 per cent) or 11 weeks (17.4 per cent) in this study that included 256 patients.

Pubmed Link

You may also be interested in

Scientific Surgery

Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial. Lancet 2017; 390: 469–479.

Authors: Rullier E, Rouanet P, Tuech J-J, Valverde A, Lelong B, Rivoire M et al.

Scientific Surgery

Adverse events and postoperative complications in a randomized trial of preoperative short-course radiotherapy versus long-course chemoradiotherapy for T3 adenocarcinoma of the rectum: Trans-Tasman Radiation Oncology Group Trial (TROG 01.04). Ann Surg 2017; 265: 882-888.

Authors: Ansari N, Solomon MJ , Fisher RJ, Mackay J, Burmeister B, Ackland S et al.

Scientific Surgery

Neoadjuvant 5-FU or capecitabine plus radiation with or without oxaliplatin in rectal cancer patients: a phase III randomized clinical trial. J Natl Cancer Inst 2015; 107.

Authors: Allegra C, Yothers G, O’Connell MJ, Beart RW, Wozniak TF, Pitot HC et al. et al.

Scientific Surgery

Clinical outcome of the ACCORD 12/0405 PRODIGE 2 randomised trial in rectal cancer. J Clin Oncol 2012; 30: 4558–4565.

Authors: Gerard JP, Azria D, Gourgou-Bourgade S, Martel-Lafay I, Hennequin C, Etienne PL et al. et al.

Scientific Surgery

Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomised phase III trial after a median follow-up of 11 years. J Clin Oncol 2012; 30: 1926–1933.

Authors: Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C et al. et al.

Scientific Surgery

Effect of oxaliplatin, fluorouracil and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer. A randomized trial. JAMA 2012; 307: 1383-1393.

Authors: Alberts SR, Sargent DJ, Nair S, Mahoney MR, Mooney M, Thibodeau NM et al. et al.

Scientific Surgery

Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine and preoperative radiotherapy with and without cetuximab followed by total mesorectal excision in patients with high risk rectal cancer (EXPERT-C). J Clin Oncol 2012; 30: 1620-1627.

Authors: Dewdney A, Cunningham D, Taberno J, Capdevila J, Glimelius B, Cervantes A et al. et al.

Scientific Surgery

Optimal duration of prophylactic antibiotic administration for elective colorectal cancer surgery: a randomized, clinical trial. Surgery 2011; 149: 171–178.

Authors: Suzuki T, Sadahiro S, Maeda Y, Tanaka A, Okada K, Kamijo A. et al.

Scientific Surgery

Evaluating an evidence-based bundle for preventing surgical site infection. A randomized trial. Arch Surg 2011; 146: 263–269.

Authors: Anthony T, Murray BW, Sum-Ping JT, Lenkovsky F, Vornik VD, Parker BJ et al.

Scientific Surgery

Enhanced recovery pathways optimise health outcomes and resource utilisation: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery 2011; 149: 830–840.

Authors: Adamina M, Kehlet H, Tomlinson GA, Senagore AJ, Delaney CP.

Scientific Surgery

Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol 2006; 24: 3542¿3547.

Authors: Smalley SR, Benedetti JK, Williamson SK, Robertson JM, Estes NC, Maher T et al.

Scientific Surgery

Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006; 93:1215-1223.

Authors: Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M for the Polish Colorectal Study Group. et al.