Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Efficacy and safety of nonantibiotic outpatient treatment in mild acute diverticulitis (DINAMO-study). A multicentre, randomised, open-label, noninferiority trial. Results from a multicenter randomized controlled trial (HOPE ECD-DBD). Ann Surg 2021; 274: e435-e442.

Authors: Mora-López L, Ruiz-Edo N, Estrada-Ferrer O, Piñana-Campón ML, Labró-Ciurans M, Escuder-Perez J et al.

Scientific Surgery

Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.

Authors: Santos A, Mentula P, Pinta T, Ismael S, Rautio T, Juusela R et al.

Scientific Surgery

Laparoscopic lavage vs primary resection for acute perforated diverticulitis. Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156: 121-127.

Authors: Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H et al.

Scientific Surgery

Prospectively randomized controlled trial on damage control surgery for perforated diverticulitis with generalized peritonitis. World J Surg 2020; 44: 4098-4105.

Authors: Kafka-Ritsch R, Zitt M, Perathoner A, Gasser E, Kaufman C, Czipin S et al.

Scientific Surgery

Emergency surgery in acute diverticulitis: a systematic review. Dis Colon Rectum 2020; 63: 397-405.

Authors: Beyer-Berjot L, Maggiori L, Loiseau D, Korwin J-D, Bongiovanni J-P, Lesprit P et al.

Scientific Surgery

Hartmann’s procedure versus sigmoidectomy with primary anastomosis for sigmoid diverticulitis with purulent or faecal peritonitis (LADIES): a multicenter, parallel-group, open label superiority trial. Lancet Gastroenterol Hepatol 2019; 4: 599-610

Authors: Lambrichts DPV, Vennix S , Musters GD , Mulder IM , Swank HA , Hoofwijk AGM et al.

Scientific Surgery

Long-term outcome of surgery versus conservative management for recurrent and ongoing complaints after an episode of diverticulitis. 5-year follow-up results of a multicenter randomized controlled trial (DIRECT-Trial). Ann Surg 2019; 269: 612-620.

Authors: Bolkenstein HE, Consten ECJ, van der Palen J, van de Wall BJ, Broeders IA, Bemelman WA et al.

Scientific Surgery

Operative strategies for perforated diverticulitis. A systematic review and meta-analysis. Dis Colon Rectum 2018; 61: 1442-1453.

Authors: Acuna SA, Wood T, Chesney TR, Dossa F, Wexner SDS, Quereshy F et al.

Scientific Surgery

The role of antibiotics in acute uncomplicated diverticulitis: A systematic review and meta-analysis. Am J Surg 2018; 216: 604–609.

Authors: Mocanu V, Dang JT, Switzer N, Tavakoli I, Tian C, de Gara C et al.

Scientific Surgery

Hartmann’s procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 2017; 225: 798-805.

Authors: Bridoux V, Regimbeau JM, Ouassi M, Mathonnet M, Mauvais F, Houivet E et al.

Scientific Surgery

Laparoscopic lavage versus primary resection for acute perforated diverticulitis: review and meta-analysis. Ann Surg 2018; 267: 252-258.

Authors: Penna M, Markar SR, Mackenzie H, Hompes R, Cunningham C

Scientific Surgery

Laparoscopic lavage in the management of Hinchey Grade III diverticulitis: a Systematic review. Ann Surg 2017; 265: 670-676.

Authors: Marshall J, Buchwald P, Gandhi J, Schultz JK, Hider PN, Frizelle F et al.

Scientific Surgery

Surgery versus conservative treatment for recurrent and ongoing left-sided diverticulitis (DIRECT Trial): an open-label, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 2017; 2: 13-22.

Authors: Van de Wall BJM, Stam MAW, Draaisma WA, Stellato R, Bemelman WA, Boermeester MA et al.

Scientific Surgery

Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 2016; 263: 117-122.

Authors: Angenete E, Thornell A, Burcharth J, Pommergaard H-C, Skullman S, Bisgaard T et al. et al.

Scientific Surgery

Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386:1269–1277.

Authors: Vennix S, Muster GD, Mulder IM, Swank HA, Consten EC, Belgers EH et al on behalf of the Ladies trial collaborators et al.

Scientific Surgery

Laparoscopic lavage vs primary resection for acute perforated diverticulitis. The SCANDIV randomized clinical trial. JAMA. 2015; 314: 1364-1375.

Authors: Schultz JK, Yaqub S, Wallon C, Blecic L, Mjørud Forsmo H, Folkesson J et al for the SCANDIV Study Group et al.

Scientific Surgery

High-dose barium impaction therapy for the recurrence of colonic diverticular bleeding: a randomized controlled trial. Ann Surg 2015; 261: 269-275.

Authors: Nagata N, Niikura R, Shimbo T, Ishizuka N, Yamano K, Mizuguchi K et al. et al.

Scientific Surgery

Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicentre randomized clinical trial (DIVER Trial). Ann Surg 2014; 259: 38-44.

Authors: Biondo S, Golda T, Kreisler E, Espin E, Vallribera F, Oteiza F et al. et al.

Scientific Surgery

A multicenter randomized clinical trial of primary anastomosis or Hartmann’s procedure for perforated left colonic diverticulitis with purulent or fecal peritonitis. Ann Surg 2012; 256: 819–827.

Authors: Oberkofler CE, Rickenbacher A, Raptis DA, Lehmann K, Villiger P, Buchli C et al.

Scientific Surgery

A prospective randomized single blind comparison of laparoscopic versus open sigmoid colectomy for diverticulitis. Ann Surg 2010; 252: 3-8.

Authors: Gervaz P, Inan I, Perneger T, Schiffer E, Morel P.

Scientific Surgery

Laparoscopic sigmoid resection for diverticulitis decreases major morbidity rates: a randomized control trial: short term results of the Sigma Trial Ann Surg 2009; 249: 39-44

Authors: Klarenbeek BR, Veenhof AA, Bergamaschi R, van der Peet DL, van den Broek WT, de Lange ES et al et al.

Scientific Surgery

Multicentre, randomized clinical trial of primary versus secondary sigmoid resection in generalized peritontius complicating sigmoid diverticultitis. Br J Surg 2000; 87: 1366-74.

Authors: Zeitoun G, Laurent A, Roufett F, Hay J-M, Fingerhut A, Paquet J-C et al. et al.