Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut 2020; 69: 859–867.

Authors: El-Salhy M, Hatlebakk JG, Gilja OH, Kristoffersen AB, Hausken T

Scientific Surgery

Luglio G, Rispo A, Imperatore N, Giglio MC, Amendola A, Tropeano FP et al. Surgical prevention of anastomotic recurrence by excluding mesentery in Crohn’s Disease: the SuPREMe-CD Study – A Randomized Clinical Trial. Ann Surg 2020; 272: 210-217.

Authors: Luglio G , Rispo A, Imperatore N, Giglio MC, Amendola A, Tropeano FP et al.

Scientific Surgery

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet 2020; 395: 1927-1936.

Authors: The HALT-IT Trial Collaborators

Scientific Surgery

Prophylactic angiographic embolisation after endoscopic control of bleeding to high-risk peptic ulcers: a randomised controlled trial. Gut 2019; 68: 796-803

Authors: Lau JYW, Pittayanon R, Wong K-T, Pinjaroen N, Chiu PWY, Rerknimitr R et al.

Scientific Surgery

A prospective randomized controlled trial of laparoscopic repair versus open repair for perforated peptic ulcers. Surgery 2016; 159: 451–458.

Authors: Ge B, Wu M, Chen Q, Chen Q, Lin R, Liu L et al.

Scientific Surgery

Double oral esomeprazole after a 3-day intravenous esomeprazole infusion reduces recurrent peptic ulcer bleeding in high-risk patients: a randomised controlled study. Gut 2014; 63: 1864-1872.

Authors: Cheng HC, Wu CT, Chang WL, Cheng WC, Chen VVY, Sheu BS et al.

Scientific Surgery

Multinational, double-blind, randomised, placebo controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study. Gut 2014; 63: 1061-1068.

Authors: Sugano K, Choi M-G, Lin J-T, Goto S, Okada Y, Kinoshita Y et al. et al.

Scientific Surgery

Enhanced postoperative recovery pathways in emergency surgery: a randomised clinical trial. Am J Surg 2014; 207: 807-814.

Authors: Gonenc M, Dural AC, Celik F, Akarsu C, Kocatas A, Kalayci MU et al. et al.

Scientific Surgery

Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice. Gut 2014; 63: 244-249.

Authors: McNicholl AG, Marin AC, Molina-Infante J, Castro M, Barrio G, Ducons J et al. et al.

Scientific Surgery

Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013; 368: 11-21.

Authors: Villanueva C, Colomo A, Bosch A, Concepcion M, Hernandez-Gea V, Aracil C et al. et al.

Scientific Surgery

Sequential versus triple therapy for the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial. Lancet 2012; 381: 205–213.

Authors: Liou JM, Chen CC, Chen MJ, Chen CC, Chang CY, Fang YJ et al. et al.

Scientific Surgery

Randomized clinical trial of vessel sealing system (LigaSure) in esophagogastric devascularisation and splenectomy in patients with portal hypertension. Am J Surg 2011; 41: 82-90.

Authors: Yao SH, Wang WJ, Wang Q, Gao WC, Xiang HG, Hu ZQ et al. et al.

Scientific Surgery

Novel approach to antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG): randomised controlled trial. BMJ 2010; 340: 81.

Authors: Blomberg J, Lagergren P, Martin L, Mattsson F, Lagergren J.

Scientific Surgery

Continuation of low-dose aspirin therapy in peptic ulcer bleeding. A randomized trial. Ann Int Med 2010; 152: 1-9.

Authors: Sung JJY, Lau JYW, Ching JYL, Wu JCY, Lee YT, Chiu PWY et al. et al.

Scientific Surgery

Recovery after open versus laparoscopic pyloromyotomy for pyloric stenosis: a double blind multicentre randomised trial Lancet 2009; 373: 390-398

Authors: Hall NJ, Pacilli M, Eaton S, Reblock K, Gaines BA, Pastor A et al et al.

Scientific Surgery

Latest results (12-21 years) of a prospective randomized study comparing Billroth II and Roux-en-Y anastomosis after a partial gastrectomy plus vagotomy in patients with duodenal ulcers Ann Surg 2009; 249: 189-194

Authors: Csendes A, Burgos AM, Smok G, Burdiles P, Braghetto I, Diaz JC et al.

Scientific Surgery

Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial Ann Intern Med 2009; 150: 455-464

Authors: Sung JJ, Barkun A, Kuipers EJ, Mossner J, Jessen DM, Stuart R et al et al.

Scientific Surgery

Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III randomised double-blind, placebo-controlled trial. Lancet 2009; 374: 119-125.

Authors: Taha AS, McCloskey C, Prasad R, Bezlyak V.

Scientific Surgery

Endoscopic clipping versus injection and thermocoagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut 2007; 56: 1364-1373.

Authors: Sung JJY, Tsoi KKF, Lai LH, Wu JCY, Lau JYW.

Scientific Surgery

Randomised trial comparing pantoprazole infusion, bolus and no treatment on gastric pH and recurrent bleeding in peptic ulcers. Aust NZ J Surg 2007; 77: 677-681.

Authors: Hung W-K, Li VKM, Chung C-K, Ying MWL, Loo C-K, Liu CKT et al.

Scientific Surgery

Omeprazole before endoscopy in patients with gastrointestinal bleeding. N Engl J Med 2007; 356: 1631-1640.

Authors: Lau JY, Leung WK, Wu JCY, Chan FKL, Wong VWS, Chiu PWY et al.

Scientific Surgery

Open versus laparoscopic pyloromyotomy for pyloric stenosis: a prospective randomised trial. Ann Surg 2006; 244: 363¿370.

Authors: St. Peter S, Holcomb GW, Calkins CM, Murphy JP, Andrews WS, Sharp RJ et al. et al.

Scientific Surgery

Percutaneous endoscopic gastrostomy placement without skin incision: results of a randomized trial. JPEN J Parenter Enteral Nutr 2006; 30: 240¿245.

Authors: Sedlack RE, Pochron NL, Baron TH.

Scientific Surgery

Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding BMJ 2005; 330: 568-570

Authors: Leontiadis GH, Sharma VK, Howden CW

Scientific Surgery

Effect of scheduled second therapeutic endoscopy on peptic ulcer rebleeding: a prospective randomised trial Gut 2003; 52: 1403-7.

Authors: Chiu PWY, Lam CYW, Lee SW, Kwong KH, Lam SH, Lee DTY et al et al.

Scientific Surgery

Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomized trial. Lancet 2002; 359: 9-13.

Authors: Chan FKL, To KF, Wu JCY, Yung MY, Leung WK, Kwok T et al. et al.

Scientific Surgery

Role of antibiotic prophylaxis for wound infection in percutaneous endoscopic gastrostomy (PEG): result of a prospective double-blind randomized trial. J Hosp Inf 2002; 50: 312-5.

Authors: Panigrahi H, Shreeve DR, Tan WC, Prudham R, Kaufman R.

Scientific Surgery

Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia. BMJ 2002; 324: 999-1002.

Authors: McColl KEL, Murray LS, Gillen D, Walker A, Wirz A, Fletcher J et al. et al.

Scientific Surgery

Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use. N Engl J Med 2002; 346: 2033-8.

Authors: Lai KC, Lam SK, Chu KM, Wong BCY, Hui WM, Hu WHC et al. et al.

Scientific Surgery

Primary prevention of diclofenac associated ulcers and dyspepsia by omeprazole or triple therapy in Helicobacter pylori positive patients:a randomised, double blind, placebo controlled, clinical trial Gut 2002; 51: 329-35.

Authors: Labenz J, Blum AL, Bolten WW, Dragosics B, Rösch W, Stolte M et al. et al.

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