This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Intraoperative goal-directed fluid therapy in elective major abdominal surgery: a meta-analysis of randomized controlled trials. Ann Surg 2016; 263: 465-476.

Published: 25th August 2016

Authors: Rollins K, Lobo D

Conclusion

There were 23 studies consisting of 2099 patients in the analysis. Goal-directed therapy reduced morbidity rates (risk ratio 0.76, 95 per cent confidence interval 0.66 to 0.89, P=0.0007) and duration of hospital stay (mean difference -1.55 days, P=0.01). The differences disappeared in patients treated in an ERAS programme.

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