This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial. Lancet 2021; 397: 2253-2263.

Published: 4th November 2021

Authors: Lopes RD, de barros e Silva PGM, Furtado RHM, Macedo AVS, Bronhara B, Damiani LP et al.

Conclusion

A total of 3331 patients with raised D-dimer were included and the outcome was a composite score of adverse events. The outcome score was similar between anticoagulant regimens in both stable and unstable patients. Bleeding was more common after therapeutic anticoagulation: 8 versus 2 per cent, P=0.001.

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Central venous access devices for the delivery of systemic anticancer therapy (CAVA): a randomised controlled trial. Lancet 2021; 398: 403-415.

Authors: Moss JG, Wo O, Bodenham AR, Agarwal R, Menne TF, Jones BL et al.

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Primary open versus closed implantation strategy for totally implantable venous access ports. The Multicentre Randomized Controlled PORTAS-3 Trial (DRKS 00004900). Ann Surg 2020; 272: 950-960.

Authors: Hüttner F, Bruckner T, Hackbusch M, Weitz J, Bork U, Kotschenreuther P et al.

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Effect of hydroxyethyl starch vs saline for volume replacement therapy on death or postoperative complications among high-risk patients undergoing major abdominal surgery. The FLASH randomized clinical trial. JAMA 2020; 323: 225-236

Authors: Futier E, Garot M, Godet T, Biais M, Verzilli D, Ouattara A et al.

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Biomarker-guided intervention to prevent acute kidney injury after major surgery: the prospective randomized BigpAK Study. Ann Surg 2018; 267: 1013-1020.

Authors: Göcze I, Jauch D, Götz M, Kennedy P, Jung B, Zeman F et al.

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Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 2018; 378: 2263-2274.

Authors: Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D et al.

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Low versus standard urine output targets in patients undergoing major abdominal surgery: a randomized noninferiority trial. Ann Surg 2017; 265: 874-881.

Authors: Puckett J, Pickering JW, Palmer S, McCall JL, Kluger MT, De Zoysa J et al.

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Assessing the efficacy and safety of eravacycline vs ertapenem in complicated intra-abdominal infections in the Investigating Gram-Negative Infections Treated with Eravacycline (IGNITE 1) trial. A randomized clinical trial. JAMA Surg 2017; 152: 224-232.

Authors: Solomkin J, Evans D , Slepavicius A, Lee P, Marsh A, Tsai L et al.

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Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial. Lancet 2016; 388: 1893–1902.

Authors: Su X, Meng Z-T, Wu X-H, Cui F, Li H-L, Wang D-X et al.

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Levosimendan for the prevention of acute organ dysfunction in sepsis. N Engl J Med 2016; 375: 1638-1648.

Authors: Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RML, Santhakumaran S et al.

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Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 2016; 388: 1377–1388.

Authors: Schaller SJ, Anstey M, Blobner M, Edrich T, Grabitz SD, Gradwohl-Matis I et al.

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Intraoperative goal-directed fluid therapy in elective major abdominal surgery: a meta-analysis of randomized controlled trials. Ann Surg 2016; 263: 465-476.

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Efficacy and safety of glutamine-supplemented parenteral nutrition in surgical ICU patients: an American multicenter randomized controlled trial. Ann Surg 2016; 263: 646-655.

Authors: Ziegler T, May A, Hebbar G, Easley KA, Griffith DP, Dave N et al.