Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Safety of combined division vs separate division of the splenic vein in patients undergoing distal pancreatectomy. A noninferiority randomized clinical trial. JAMA Surg 2021; 156: 418-428.

Authors: Yamada S, Fujii T, Sonohara F, Kawai M, Shibuya K, Matsumoto I et al.

Scientific Surgery

Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 438-447.

Authors: Wang M, Li D, Chen R, Huang X, Li J, Liu Y et al.

Scientific Surgery

Nasogastric decompression vs no decompression after pancreaticoduodenectomy. The randomized clinical IPOD Trial. JAMA Surg 2020; 155: e202291.

Authors: Bergeat D, Merdrignac A, Robin F, Gaignard E, Rayar M, Meunier B et al.

Scientific Surgery

Pancreatoduodenectomy with epidural vs patient-controlled intravenous analgesia. A randomized clinical trial. JAMA Surg 2020; 155: e200794.

Authors: Klotz R, Larmann J, Klose C, Bruckner T, Benner L, Doerr-Harim C et al.

Scientific Surgery

A systematic review and network-meta-analysis of gastro-enteric reconstruction techniques following pancreatoduodenectomy to reduce delayed gastric emptying. World J Surg 2020; 44: 2314-2322.

Authors: Kamarajah SK, Bundred JR, Alessandri G, Robinson SM, Wilson CH, French JJ et al.

Scientific Surgery

Pancreaticojejunostomy with externalized stent vs pancreaticogastrostomy with externalized stent for patients with high-risk pancreatic anastomosis. A single-center, phase 3, randomized clinical trial. JAMA Surg 2020; 155: 313-321.

Authors: Andrianello S, Marchegiani G, Malleo G, Masini G, Balduzzi A, Paiella S et al.

Scientific Surgery

Effect of hydrocortisone vs pasireotide on pancreatic surgery complications in patients with high risk of pancreatic fistula. A randomized clinical trial. JAMA Surg 2020; 155: 291-298.

Authors: Tarvainen T, Siren J, Kokkola A, Sallinen V

Scientific Surgery

Neoadjuvant therapy for resectable and borderline resectable pancreatic cancer: a meta-analysis of randomized controlled trials. J Clin Med. 2020; 9: 1129.

Authors: Cloyd JM, Heh V, Pawlik TM, Ejaz A, Dillhoff M, Tsung A et al.

Scientific Surgery

Results of a randomized controlled trial comparing closed-suction drains versus passive gravity drains after pancreatic resection. Surgery 2018; 164: 1057-1063.

Authors: Čečka F, Jon B, Skalický P, Čermáková E, Neoral C, Loveček M et al.

Scientific Surgery

Modified Blumgart mattress suture versus conventional interrupted suture in pancreaticojejunostomy during pancreaticoduodenectomy. Randomized controlled trial. Ann Surg 2019; 269: 243–251.

Authors: Hirono S, Kawai M, Okada K-I, Miyazawa M, Kitahata Y, Hayami S et al.

Scientific Surgery

FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Engl J Med 2018; 379: 2395-2406.

Authors: Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC, Raoul J-L et al.

Scientific Surgery

Minimally invasive versus open distal pancreatectomy (LEOPARD). A multicenter patient-blinded randomized controlled trial. Ann Surg 2019; 269: 2-9.

Authors: de Rooij T, van Hilst J, van Santvoort H, Boerma D, van den Boezem P, Daams F et al.

Scientific Surgery

Comparison of perioperative outcomes between laparoscopic and open approach for pancreatoduodenectomy: the PADULAP randomized controlled trial. Ann Surg 2018; 268: 731-739.

Authors: Poves I, Burdío F, Morató O, Iglesias M, Radosevic A, Ilzarbe L et al.

Scientific Surgery

Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2/3 trial. Ann Surg 2018; 268: 215-222.

Authors: Jang J-Y, Han Y, Lee H, Kim S-W, Kwon W, Lee K-H et al.

Scientific Surgery

Pylorus resection does not reduce delayed gastric emptying after partial pancreatoduodenectomy: a blinded randomized controlled trial (PROPP Study, DRKS00004191). Ann Surg 2018; 267: 1021-1027.

Authors: Hackert T, Probst P, Knebel P, Doerr-Harim C, Bruckner T, Klaiber U et al.

Scientific Surgery

CONKO-005: Adjuvant chemotherapy with gemcitabine plus erlotinib versus gemcitabine alone in patients after R0 resection of pancreatic cancer: a multicenter randomized phase III trial. J Clin Oncol 2017; 35: 3330-3337.

Authors: Sinn M, Bahra M, Liersch T, Gellert K, Messmann H, Bechstein W et al.

Scientific Surgery

A Prospective randomized multicenter trial of distal pancreatectomy with and without routine intraperitoneal drainage. Ann Surg 2017; 266: 421-431.

Authors: Van Buren G , Bloomston M, Schmidt CR, Behrman SW, Zyromski NJ, Ball C et al.

Scientific Surgery

Effect of polyglycolic acid mesh for prevention of pancreatic fistula following distal pancreatectomy. A randomized clinical trial. JAMA Surg 2017; 152: 150-155.

Authors: Jang J-Y, Shin YC, Han YM, Park JS, Han H-S, Hwang HK et al.

Scientific Surgery

Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. Lancet 2017; 389: 1011–24.

Authors: Neoptolemos JP, Palmer DH, Ghaneh P, Psarelli EE, Valle JW, Halloran CM et al.

Scientific Surgery

The cost of postoperative pancreatic fistula versus the cost of pasireotide: results from a prospective randomized trial. Ann Surg 2017; 265: 11-16.

Authors: Ma LW , Dominguez-Rosado I, Gennarelli RL, Bach PB, Gonen M, D’Angelica M et al.

Scientific Surgery

Teres ligament patch reduces relevant morbidity after distal pancreatectomy (the DISCOVER randomized controlled trial). Ann Surg 2016; 264: 723-730.

Authors: Hassenpflug M, Hinz U, Strobel O, Volpert J, Knebel P, Diener M et al.

Scientific Surgery

Prospective randomized controlled trial of liberal vs. restricted perioperative fluid management in patients undergoing pancreatectomy. Ann Surg 2016; 264: 591-598.

Authors: Grant F, Brennan MF, Allen PJ,, DeMatteo RP, Kingham TP, D’Angelica M et al.

Scientific Surgery

No need for routine drainage after pancreatic head resection: the dual-center, randomized controlled PANDRA Trial. Ann Surg 2016; 264: 528-537.

Authors: Witzigmann H, Diener MK, Kienkötter S, Rossion I, Bruckner T, Bärbel W et al.

Scientific Surgery

Evaluation of the efficacy of daikenchuto (TJ -100) for the prevention of paralytic ileus after pancreaticoduodenectomy: A multicenter, double-blind, randomized, placebo-controlled trial. Surgery 2016; 159: 1333–1341.

Authors: Okada K-I, Kawai M, Hirono S, Fujii T, Kodera Y, Sho M et al.

Scientific Surgery

Randomized controlled trial of pancreaticojejunostomy versus stapler closure of the pancreatic stump during distal pancreatectomy to reduce pancreatic fistula. Ann Surg 2016; 264: 180-187.

Authors: Kawai M, Hirono S, Okada K, Sho M, Nakajima Y, Eguchi H et al.

Scientific Surgery

Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 2016; 388: 248–25716.

Authors: Uesaka K, Boku N, Kukutomi A, Okamura Y, Knoishi M, Matsumoto I et al.

Scientific Surgery

Pancreaticogastrostomy is superior to pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: an updated meta-analysis of randomized controlled trials. Ann Surg 2015; 261: 882–887.

Authors: Menahem B, Guittet L, Mulliri A, Alves A, Lubrano J

Scientific Surgery

Pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy: a meta-analysis of randomized control trials. Eur J Surg Oncol 2014; 40: 1177-1185.

Authors: Chen Z, Song X, Yang D, Li Y, Xu K, He Y et al. et al.

Scientific Surgery

A prospective randomized controlled study comparing outcomes of standard resection and extended resection, including dissection of the nerve plexus and various lymph nodes, in patients with pancreatic cancer. Ann Surg 2014; 259: 656-664.

Authors: Jang J-Y, Kang MJ, Heo JS, Choi SH, Choi DW, Park SJ et al. et al.

Scientific Surgery

A randomized prospective multicentre trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage. Ann Surg 2014; 259: 605-612.

Authors: Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman S, Zyromski NJ et al. et al.

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