Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 569-577.

Authors: Park JW, Kang S-B, Hao J, Lim S-B, Choi HS, Kim D-W et al.

Scientific Surgery

Perioperative systemic therapy vs cytoreductive surgery and hyperthermic intraperitoneal chemotherapy alone for resectable colorectal peritoneal metastases. A phase 2 randomized clinical trial. JAMA Surg 2021; 156: 710-720.

Authors: Rovers KP, Bakkers C, Nienhuijs SW, Burger JWA, Creemers G-JM, Thijs AMJ et al.

Scientific Surgery

Colonic J-pouch or straight colorectal reconstruction after low anterior resection for rectal cancer: impact on quality of life and bowel function: a multicenter prospective randomized study. Dis Colon Rectum 2020; 63: 1511-1523.

Authors: Gavaruzzi T, Pace U, Giandomenico F, Pucciarelli S, Bianco F, Selvaggi F et al.

Scientific Surgery

Meta-analysis and trial sequential analysis of randomized controlled trials comparing high and low ligation of the inferior mesenteric artery in rectal cancer surgery. Dis Colon Rectum 2020; 63: 988-999.

Authors: Hajibandeh S, Hajibandeh S, Maw A

Scientific Surgery

Two-stage Turnbull-Cutait pull-through coloanal anastomosis for low rectal cancer. A randomized clinical trial. JAMA Surg 2020; 155: e201625.

Authors: Biondo S, Trenti L, Espin E, Bianco F, Barrios O, Falato A et al.

Scientific Surgery

Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial. Lancet Gastroenterol Hepatol 2020; 5: 465-474.

Authors: Rullier E, Vendrely V, Rouanet P, Tuech JJ, Valverde A

Scientific Surgery

Low ligation of inferior mesenteric artery in laparoscopic anterior resection for rectal cancer reduces genitourinary dysfunction. Results from a randomized controlled trial (HIGHLOW Trial). Ann Surg 2019; 269: 1018-1024.

Authors: Mari G, Crippa J, Cocozza E, Berselli M, Livraghi L, Carzaniga P et al.

Scientific Surgery

Laparoscopic versus open resection for rectal cancer. A non-inferiority meta-analysis of quality of surgical resection outcomes. Ann Surg 2019; 269: 849-855.

Authors: Acuna SA, Chesney TR, Ramjist JK, Shah PS, Kennedy ED, Naxter NN et al.

Scientific Surgery

Clinical outcome after rectal replacement with side-to-end, colon-J-pouch, or straight colorectal anastomosis following total mesorectal excision. A Swiss Prospective, Randomized, Multicenter Trial (SAKK 40/04). Ann Surg 2019; 269: 827-835.

Authors: Marti W, Curti G, Wehrli H, Grieder F, Graf M, Gloor B et al.

Scientific Surgery

Better function with a colonic J-pouch or a side-to-end anastomosis? A randomized controlled trial to compare the complications, functional outcome, and quality of life in patients with low rectal cancer after a J-pouch or a side-to-end anastomosis. Ann Surg 2019; 269: 815-826.

Authors: Parc Y, Ruppert R, Fuerst A, Golcher H, Zutshi M, Hull T et al.

Scientific Surgery

A meta-analysis of randomized controlled trials on the use of suction drains following rectal surgery. Dig Surg 2018; 35: 482–490.

Authors: Guerra F, Giuliani G, Coletta D, Boni M, Rondelli F, Bianchi PP et al.

Scientific Surgery

Robotic versus laparoscopic minimally invasive surgery for rectal cancer: a systematic review and meta-analysis of randomized controlled trials. Ann Surg 2018; 267: 1034-1046.

Authors: Prete FP, Pezzolla A, Prete F, Testini M, Marzaioli R, Patriti A et al.

Scientific Surgery

Tattooing improves the detection of small lymph nodes and increases the number of retrieved lymph nodes in patients with rectal cancer who receive preoperative chemoradiotherapy: a randomized controlled clinical trial. Am J Surg 2018; 215: 563-569.

Authors: Okada K, Sahahiro S, Ogimi T, Miyakita H, Saito G, Tanaka A et al.

Scientific Surgery

Robot-assisted versus laparoscopic surgery for rectal cancer: a phase II open label prospective randomized controlled trial. Ann Surg 2018; 267: 243-251.

Authors: Kim MJ, Park SC, Park JW, Chang HJ, Kim DY, Nam B-H et al.

Scientific Surgery

Effect of robotic-assisted vs conventional laparoscopic surgery on risk of conversion to open laparotomy among patients undergoing resection for rectal cancer. The ROLARR randomized clinical trial. JAMA 2017; 318: 1569-1580.

Authors: Jayne D, Pigazzi A, Marshall H, Croft J, Corrigan N, Copeland J et al.

Scientific Surgery

Biological mesh closure of the pelvic floor after extralevator abdominoperineal resection for rectal cancer; a multicenter randomized controlled trial (the BIOPEX study). Ann Surg 2017; 265: 1074-1081.

Authors: Musters G, Klaver CE, Bosker RJI, Burger JWA, van Duijvendijk P, van Etten B et al.

Scientific Surgery

Biological mesh closure of the pelvic floor after extralevator abdominoperineal resection for rectal cancer: a multicenter randomized controlled trial (the BIOPEX-study). Ann Surg 2017; 265: 1074-1081.

Authors: Musters G, Klaver CEL, Bosker R, Burger J, van Duijvendijk P, van Etten B et al.

Scientific Surgery

To drain or not to drain infraperitoneal anastomosis after rectal excision for cancer: The GRECCAR 5 randomized trial. Ann Surg 2017; 265: 474-480.

Authors: Denost Q, Rouanet P, Faucheron J-L, Panis Y, Meunier B, Cotte E et al.

Scientific Surgery

Male sexual dysfunction after rectal cancer surgery: results of a randomized trial comparing mesorectal excision with and without lateral lymph node dissection for patients with lower rectal cancer: Japan Clinical Oncology Group Study JCOG0212. Eur J Surg Oncol 2016; 42: 1851–1858.

Authors: Saito S, Fujita S, Mizusawa J, Kanemitsu Y, Saito N, Kinugasa Y et al.

Scientific Surgery

Diverting ileostomy versus no diversion after low anterior resection for rectal cancer: a prospective, randomized, multicenter trial. Surgery 2016; 159: 1129–1139.

Authors: Mrak K, Uranitsch F, Pedross F, Heuberger A, Klinger A, Jagoditsch M et al.

Scientific Surgery

Effect of laparoscopic-assisted resection vs open resection on pathological outcomes in rectal cancer. The ALaCaRT Randomized Clinical Trial. JAMA 2015; 314: 1356-1363.

Authors: Stevenson ARL, Solomon MJ, Lumley JW, Hewett P, Clouston AD, Gebski VJ et al et al.

Scientific Surgery

Effect of laparoscopic-assisted resection vs open resection of stage II or III rectal cancer on pathologic outcomes. The ACOSOG Z6051 Randomized Clinical Trial. JAMA 2015; 314: 1346-1355.

Authors: Fleshman J, Branda M, Sargent DJ, Boller AM, George V, Abbas M et al. et al.

Scientific Surgery

Biosorbable staple line reinforcement in restorative proctectomy and anterior resection: a randomized study. Dis Colon Rectum 2014; 57: 323-330.

Authors: Senagore A, Lane FR, Lee E, Wexner S, Dujovny N, Sklow B et al. et al.

Scientific Surgery

Reduction of postoperative ileus by early enteral nutrition in patients undergoing major rectal surgery: prospective, randomized controlled trial. Ann Surg 2014; 259: 649-655.

Authors: Boelens P, Heesakkers FB, Luyer DP, van Barnevld KWY, de Hingh IH, Nieuwenhuijzen GA et al.

Scientific Surgery

Can transanal tube placement after anterior resection for rectal carcinoma reduce anastomotic leakage rate? A single institution prospective randomized study. World J Surg 2011; 35: 1367–1377.

Authors: Xiao L, Zhang W, Jiang P-C, Bu X-F, Yan Q, Li H et al.

Scientific Surgery

End-to-end versus end-to-side stapled anastomosis after anterior resection for rectal cancer J Surg Oncol 2009; 99: 75-79

Authors: Brisinda G, Vanella S, Cadeddu F, Civello IM, Brandara F, Nigro C et al et al.

Scientific Surgery

Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomised multicenter trial. Ann Surg 2007; 246: 207-214.

Authors: Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R.

Scientific Surgery

The TME trial after a median follow-up of six years: local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007; 246: 693-701.

Authors: Peeters KCMJ, Marijnen CAM, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T et al.

Scientific Surgery

Meta-analysis of colonic reservoirs versus straight coloanal anastomosis after anterior resection. Br J Surg 2006; 93: 19-32.

Authors: Heriot AG, Tekkis PP, Constantinides V, Paraskevas P, Nichols RJ, Darzi A et al.

Scientific Surgery

Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Br J Surg 2006; 93: 169¿174.

Authors: Chetter IC, Mylankal KJ, Hughes H, Fitridge R.

Older Entries