Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Long-term clinical and cost-effectiveness of early endovenous ablation in venous ulceration. A randomized clinical trial. JAMA Surg 2020; 155: 1113-1121.

Authors: Gohel M, Mora J, Szigeti M, Epstein DM, Heatley F, Bradbury A et al.

Scientific Surgery

A randomized trial of class 2 and class 3 elastic compression in the prevention of recurrence of venous ulceration. J Vacs Surg Venous Lymphat Disord 2018; 6: 717–723.

Authors: Milic DJ, Zivic SS, Bogdanovic DC, Golubovic MD, Lazarevic MV, Lazarevic KK et al.

Scientific Surgery

A randomized trial of early endovenous ablation in venous ulceration. N Engl J Med 2018; 378: 2105-2114.

Authors: Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N et al.

Scientific Surgery

Low dose aspirin as adjuvant treatment for venous leg ulceration. BMJ 2017: 359: j5157.

Authors: Jull A, Wadham A, Bullen C, Parag V, Kerse N, Waters J et al.

Scientific Surgery

Handcrafted vacuum-assisted device for skin ulcers treatment versus traditional therapy, randomized controlled trial. World J Surg 2017; 41: 386–393.

Authors: Gonzalez IG, Angel MAL, Baez MVJ, Flores BR, Ferretiz MDM, Woolf SV et al.

Scientific Surgery

Clinical and cost-effectiveness of compression hosiery versus compression bandages in treatment of venous leg ulcers (Venous leg Ulcer Study IV, VenUS IV): a randomised controlled trial. Lancet 2014; 383:871-879.

Authors: Ashby RL, Gabe R, Ali S, Adderley U, Bland JM, Cullum NA et al. et al.

Scientific Surgery

The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts. J Vasc Surg 2013; 58: 433–439.

Authors: Lantis JC, Marston WA, Farber A, Kirsner RS, Zhang Y, Lee TD et al. et al.

Scientific Surgery

Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. Lancet 2012; 380: 977–985.

Authors: Kirsner RS, Marston WA, Snyder RJ, Lee TD, Cargill DI, Slade HB et al.

Scientific Surgery

Randomized controlled trial comparing treatment outcome of two compression bandaging systems and standard care without compression in venous leg ulcers. J Vasc Surg 2012; 55: 1376-1385.

Authors: Wong IKY, Andriessen A, Lee DTF, Thompson D, Wong LY, Chao DVK et al. et al.

Scientific Surgery

Use of weekly, low dose, high frequency ultrasound for hard to heal venous leg ulcers: the VenUS III randomised controlled trial. BMJ 2011; 342: 585.

Authors: Watson JM, Kang’ombe AR, Soares MO, Chuang L-H, Worthy G, Bland JM et al. et al.

Scientific Surgery

Modern wound care for the poor: a randomized clinical trial comparing the vacuum system with conventional saline soaked gauze dressings. Am J Surg 2010; 199: 14-20.

Authors: Perez D, Bramkamp M, Exe C, von Ruden C, Ziegler A.

Scientific Surgery

Randomised clinical trial of foam sclerotherapy in patients with a venous leg ulcer. Eur J Vasc Endovasc Surg 2010; 39: 495-499.

Authors: O'Hare JL, Earnshaw JJ.

Scientific Surgery

Larval therapy for leg ulcers (VenUS II): randomised controlled trial BMJ 2009; 338: 1047-1057

Authors: Dumville JC, Worthy G, Bland JM, Cullum N, Dowson C, Iglesias C et al et al.

Scientific Surgery

Cost effectiveness analysis of larval therapy for leg ulcers BMJ 2009; 338: 1050-1054

Authors: Soares MO, Iglesias CP, Bland JM, Cullum N, Dumville JC, Nelson EA et al et al.

Scientific Surgery

Four layer bandage compared with short stretch bandage for venous leg ulcers: systematic review and meta-analysis of randomised controlled trials with data from individual patients BMJ 2009; 338: 1054-1057

Authors: O'Meara SA, Tierney J, Cullum N, Bland JM, Franks PJ, Mole T et al et al.

Scientific Surgery

Randomised trial of balneotherapy associated with patient education in patients with advanced chronic venous insufficiency J Vasc Surg 2009; 49: 163-170

Authors: Carpentier PH, Satger B

Scientific Surgery

In search of optimal compression therapy for venous leg ulcers: a meta-analysis of studies comparing divers bandages with specifically designed stockings. J Vasc Surg 2009; 50: 668-674.

Authors: Amsler F, Willenberg T, Blatter W.

Scientific Surgery

Treatment of pressure ulcers. A systematic review JAMA 2008; 300: 2647-2662

Authors: Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA et al.

Scientific Surgery

A randomized double blind, multicentre clinical trial comparing the efficacy of calcium dobesilate with placebo in the treatment of chronic venous disease. Eur J Vasc Endovasc Surg 2008; 35: 358-365.

Authors: Martinez-Zapata MJ, Moreno RM, Gich I, Urrutia G, Bonfill X.

Scientific Surgery

Occlusive vs. gauze dressings for local wound care in surgical patients. A randomized clinical trial Arch Surg 2008; 143: 950-955

Authors: Ubbink D, Vermeulen H, Goossens A, Kelner R, Schreuder S, Lubbers M et al.

Scientific Surgery

A randomized trial of Tubulcus multilayer bandaging system in the treatment of extensive venous ulcers. J Vasc Surg 2007; 46: 750-755.

Authors: Milic DJ, Zivic SS, Bogdanovic DC, Perisic ZD, Milosevic ZD Jankovic RJ.

Scientific Surgery

Efficacy of topical pale sulphonated shale oil in the treatment of venous leg ulcers: a randomized controlled multicenter study. J Vasc Surg 2006; 43: 94-100.

Authors: Beckert S, Warnecke J, Zelenkova H, Kovnerystyy O, Stege H, Cholcha W et al.

Scientific Surgery

Preventing pressure ulcers: a systematic review. JAMA 2006; 296: 974-984.

Authors: Reddy M, Gill SS, Rochon PA.

Scientific Surgery

Conservative versus surgical treatment of venous leg ulcers: a prospective, randomised, multicenter trial. J Vasc Surg 2006; 44: 563¿571.

Authors: van Gent WB, Hop WC, van Praag MC, Mackaay AJ, de Boer EM, Wittens CH. et al.

Scientific Surgery

State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (VAC) with modern wound dressings. J Vasc Surg 2006; 44: 1029¿1037.

Authors: Vuerstaek JDD, Vainas T, Wuite J, Nelemans P, Neumann MHA, Veraate JCJM. et al.

Scientific Surgery

A systematic review of randomized controlled trials of wound dressings for chronic venous ulcer. J Vasc Surg 2006; 44: 1118¿1125.

Authors: O¿Donnell TF, Lau J.

Scientific Surgery

Randomized clinical trial of compression plus surgery versus compression alone in chronic venous ulceration (ESCHAR study) ¿ haemodynamic and anatomical changes. Br J Surg 2005; 92: 291-297.

Authors: Gohel MS, Barwell JR, Earnshaw JJ, Heather BP, Mitchell DC, Whyman MR et al.

Scientific Surgery

Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction. Eur J Vasc Endovasc Surg 2005; 30: 198-208.

Authors: Coleridge-Smith P, Lok C, Ramelet A-A.

Scientific Surgery

Comparison of elastic versus nonelastic compression in bilateral venous ulcers: a randomized trial. J Vasc Surg 2005; 42: 1150-1155.

Authors: Blecken SR, Villavicencio JL, Kao TC.

Scientific Surgery

Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial J Vasc Surg 2005; 41: 837-843.

Authors: VAS004. Mostow EN, Haraway GD, Dalsing M, Hodde JP, King D. .

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