Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA. N Engl J Med 2020; 383: 207-217.

Authors: Claiborne Johnston S, Amarenco P, Denison H, Evans SR, Himmelmann A, James S et al.

Scientific Surgery

Rivaroxaban in peripheral artery disease after revascularization. N Engl J Med 2020; 382: 1994-2004.

Authors: Bonaca MP, Bauersachs RM, Anand S, Debus ES, Nehler MR, Patel MR et al.

Scientific Surgery

Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis. Lancet 2020; 395: 1487-1495.

Authors: Chiarito M, Sanz-Sanchez J, Cannata F, Cao D, Sturla M, Panico C et al.

Scientific Surgery

Rivaroxaban with or without aspirin in patients with heart failure and chronic coronary or peripheral artery disease. The COMPASS Trial. Circulation 2019; 140: 529-537

Authors: Branch KR, Probstfield JL, Eikelboom JW, Bosch J, Maggioni AP, Cheng RK et al.

Scientific Surgery

No clinical benefit of intramuscular delivery of bone marrow-derived mononuclear cells in nonreconstructable peripheral arterial disease: results of a phase-III randomized-controlled trial. Ann Surg 2018; 268: 756-761.

Authors: Lindeman J, Zwaginga J, Kallenberg-Lantrua G, van Wissen RC, Schepers A, van Bockel HJ et al.

Scientific Surgery

A systematic review of the efficacy of aspirin monotherapy versus other antiplatelet therapy regimens in peripheral arterial disease. J Vasc Surg 2018; 67: 1922-1932.

Authors: Beiswenger AC, Jo A, Harth K, Kumins NH, Shishehbor MH, Kashyap VS et al.

Scientific Surgery

Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med 2018; 379: 215-225.

Authors: Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ et al.

Scientific Surgery

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials. Lancet 2018; 392: 387–399.

Authors: Rothwell PM, Cook NR, Gaziano JM, Price JF, Belch JFF, Roncaglioni MC et al.

Scientific Surgery

Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet 2018; 391: 219-229.

Authors: Anand S, Bosch J, Eikelboom JW, Connolly SJ, Diaz R, Widimsky P et al.

Scientific Surgery

Efficacy and safety of aspirin in patients with peripheral vascular disease: an updated systematic review and meta-analysis of randomized controlled trials. PLoS ONE 2017; 12: e0175283.

Authors: Mahmoud AN, Elgendy AY, Rambarat C, Mahtta D, Elgendy IY, Bavry AA et al.

Scientific Surgery

Evaluation of cell therapy on exercise performance and limb perfusion in peripheral artery disease. Circulation. 2017; 135: 1417-1428.

Authors: Perin EC, Murphy MP, March KL, Bolli R, Loughran J, Yang PC et al.

Scientific Surgery

Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med 2017; 377: 1319-1330.

Authors: Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O et al.

Scientific Surgery

Efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease Fontaine stage IV: results of a placebo-controlled randomized multicenter trial (ESPECIAL). Eur J Vasc Endovasc Surg 2017; 53: 559-566.

Authors: Lawall H, Pokrovsky A, Checinski P, Ratushnyuk A, Hamm G, Randerath O et al.

Scientific Surgery

Low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes mellitus. 10-year follow-up of a randomized controlled trial. Circulation. 2017; 135: 659-670.

Authors: Saito Y, Okada S, Ogawa H, Soejima H, Sakuma M, Nakayama M et al.

Scientific Surgery

Ticagrelor compared with clopidogrel in patients with prior lower extremity revascularization for peripheral artery disease. Circulation. 2017; 135: 241-250.

Authors: Schuyler Jones W, Baumgartner I, Hiatt WR, Heizer G, Conte MS, White CJ et al.

Scientific Surgery

Evacetrapib and cardiovascular outcomes in high-risk vascular disease. N Engl J Med 2017; 376: 1933-1942.

Authors: Lincoff AM, Nicholls SJ, Riesmeyer JS, Barter PJ, Brewer HB, Fox KAA et al.

Scientific Surgery

Ticagrelor versus clopidogrel in symptomatic peripheral artery disease. N Engl J Med 2017; 376: 32-40.

Authors: Hiatt WR, Fowkes GR, Heizer G, Berger JS, Baumgartner I, Held P et al.

Scientific Surgery

Polymyalgia rheumatica and giant cell arteritis: a systematic review. JAMA 2016; 315: 2442-2458.

Authors: Buttgereit F, Dejaco C, Matteson EL, Dasgupta B

Scientific Surgery

Bone marrow derived cell therapy in critical limb ischaemia: a meta-analysis of randomized placebo controlled studies. Eur J Vasc Endovasc Surg 2015; 50: 775-783.

Authors: Peeters Weem SMO, Teraa M, de Borst GJ, Verhaar MC, Moll FL

Scientific Surgery

Effect of repetitive intra-arterial infusion of bone marrow mononuclear cells in patients with no-option limb ischemia. The randomized, double-blind, placebo-controlled reJuvenating ENdothelial progenitor cells via Transcutaneous intra-Arterial Supplementation (JUVENTAS) Trial. Circulation. 2015; 131: 851-860.

Authors: Teraa, M, Sprengers RW, Schutgens REG, Slaper-Cortenbach ICM, van der Graaf Y et al.

Scientific Surgery

Beneficial effects of pre-operative exercise therapy in patients with an abdominal aortic aneurysm: a systematic review. Eur J Vasc Endovasc Surg 2015; 49: 66-76.

Authors: Pouwels S, Willigendael EM, van Sambeek MR, Nienhuijs SW, Cuypers PW, Teijink JA et al.

Scientific Surgery

Autologous bone marrow-derived cell therapy in patients with critical limb ischemia: a meta-analysis of randomized controlled clinical trials. Ann Surg 2013; 258: 922–929.

Authors: Teraa M, Sprengers RW, van der Graaf Y, Peters CEJ, Moll FL, Verhaar MC et al.

Scientific Surgery

Effect of ramipril on walking times and quality of life among patients with peripheral artery disease and intermittent claudication: A randomized controlled trial. JAMA 2013; 309: 453–460.

Authors: Ahimastos AA, Walker PJ, Askew C, Leicht A, Pappas E, Blombery P et al. et al.

Scientific Surgery

Internet based vascular risk factor management for patients with clinically manifest vascular disease: randomised controlled trial. BMJ 2012; 344: e3750.

Authors: Vernooij JWP, Kaasjager HAH, van der Graaf Y, Wierdsma J, Grandjean HMH, Hovens MMC et al. et al.

Scientific Surgery

Early results and lessons learned from a multicentre, randomized, double-blind trial of bone marrow aspirate concentrate in critical limb ischaemia. J Vasc Surg 2011; 54: 1650-1658.

Authors: Iafrati MD, Hallett JW, Gells G, Pearl G, Lumsden A, Peden E et al.

Scientific Surgery

Interim analysis results from the RESTORE-CLI, a randomized, double-blind multicentre phase II trial comparing expanded autologous bone marrow-derived tissue repair cells and placebo in patients with critical limb ischemia. J Vasc Surg 2011; 54: 1032–1041.

Authors: Powell RJ, Comerota AJ, Berceli SA, Guzman R, Henry TD, Tzeng E et al.

Scientific Surgery

Effect of fibroblast growth factor NV1FGF on amputation and death: a randomised placebo-controlled trial of gene therapy in critical limb ischaemia. Lancet 2011; 377: 1929–1937.

Authors: Belch J, Hiatt WR, Baumgartner I, Driver IV, Nikol S, Norgren L et al. et al.

Scientific Surgery

The Scottish-Finnish-Swedish PARTNER study of taprostene versus placebo treatment in patients with critical limb ischaemia. Int Angiol 2011; 30: 150-155.

Authors: Belch JJF, Ray S, Rajput-Ray M, Engeset J, Fagrell B, Lepantalo M et al. et al.

Scientific Surgery

Safety and efficacy of patient specific intramuscular injection of HGF plasmid gene therapy on limb perfusion and wound healing in patients with ischemic lower extremity ulceration: results of the HGF-0205 trial. J Vasc Surg 2010; 52: 1525-1530.

Authors: Powell RJ, Goodney P, Mendelsohn FO, Moen EK, Annex BH for the HGF-0205 Trial Investigators.

Scientific Surgery

Efficacy and safety of alfimeprase in patients with acute peripheral arterial occlusion. J Vasc Surg 2010; 51: 600-609.

Authors: Han SM, Weaver FA, Comerota AJ, Perler BA, Joing M.

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