Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Efficacy and safety of udenafil for the treatment of erectile dysfunction after total mesorectal excision of rectal cancer: a randomized, double-blind, placebo-controlled trial. Surgery 2015; 157: 64-71.

Authors: Park SY, Choi G-S, Park JS, Kim HJ, Park J-A, Choi JI et al.

Scientific Surgery

Biosorbable staple line reinforcement in restorative proctectomy and anterior resection: a randomized study. Dis Colon Rectum 2014; 57: 323-330.

Authors: Senagore A, Lane FR, Lee E, Wexner S, Dujovny N, Sklow B et al. et al.

Scientific Surgery

Reduction of postoperative ileus by early enteral nutrition in patients undergoing major rectal surgery: prospective, randomized controlled trial. Ann Surg 2014; 259: 649-655.

Authors: Boelens P, Heesakkers FB, Luyer DP, van Barnevld KWY, de Hingh IH, Nieuwenhuijzen GA et al.

Scientific Surgery

Clinical outcome of the ACCORD 12/0405 PRODIGE 2 randomised trial in rectal cancer. J Clin Oncol 2012; 30: 4558–4565.

Authors: Gerard JP, Azria D, Gourgou-Bourgade S, Martel-Lafay I, Hennequin C, Etienne PL et al. et al.

Scientific Surgery

Randomized controlled trial of tamsulosin for prevention of acute voiding difficulty after rectal cancer surgery. World J Surg 2012; 36: 2730–2737.

Authors: Jang J-H, Kang S-B, Lee S-M, Park J-S, Kim D-W, Ahn S et al.

Scientific Surgery

Ciclosporin versus infliximab in patients with severe ulcerative colitis refractory to intravenous steroids: a parallel, open-label randomised controlled trial. Lancet 2012; 380: 1909–1915.

Authors: Laharie D, Bourreille A, Branche J, Allez M, Bouhnik Y, Filippi J et al. et al.

Scientific Surgery

Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomised phase III trial after a median follow-up of 11 years. J Clin Oncol 2012; 30: 1926–1933.

Authors: Sauer R, Liersch T, Merkel S, Fietkau R, Hohenberger W, Hess C et al. et al.

Scientific Surgery

Effect of oxaliplatin, fluorouracil and leucovorin with or without cetuximab on survival among patients with resected stage III colon cancer. A randomized trial. JAMA 2012; 307: 1383-1393.

Authors: Alberts SR, Sargent DJ, Nair S, Mahoney MR, Mooney M, Thibodeau NM et al. et al.

Scientific Surgery

Multicenter randomized phase II clinical trial comparing neoadjuvant oxaliplatin, capecitabine and preoperative radiotherapy with and without cetuximab followed by total mesorectal excision in patients with high risk rectal cancer (EXPERT-C). J Clin Oncol 2012; 30: 1620-1627.

Authors: Dewdney A, Cunningham D, Taberno J, Capdevila J, Glimelius B, Cervantes A et al. et al.

Scientific Surgery

Phase III trial assessing bevacizumab in stages II and III carcinoma of the colon: results of NSABP protocol C-08. J Clin Oncol 2011; 29: 1-14.

Authors: Allegra CJ, Yothers G, O’Connell MJ, Sharif S, Petrelli NJ, Colangelo LH et al.

Scientific Surgery

Optimal duration of prophylactic antibiotic administration for elective colorectal cancer surgery: a randomized, clinical trial. Surgery 2011; 149: 171–178.

Authors: Suzuki T, Sadahiro S, Maeda Y, Tanaka A, Okada K, Kamijo A. et al.

Scientific Surgery

Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. Lancet 2011; 377: 1749–1759.

Authors: Seymour MT, Thompson LC, Wasan HS, Middleton G, Brewster AE, Shepherd SF et al.

Scientific Surgery

Evaluating an evidence-based bundle for preventing surgical site infection. A randomized trial. Arch Surg 2011; 146: 263–269.

Authors: Anthony T, Murray BW, Sum-Ping JT, Lenkovsky F, Vornik VD, Parker BJ et al.

Scientific Surgery

Enhanced recovery pathways optimise health outcomes and resource utilisation: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery 2011; 149: 830–840.

Authors: Adamina M, Kehlet H, Tomlinson GA, Senagore AJ, Delaney CP.

Scientific Surgery

Can transanal tube placement after anterior resection for rectal carcinoma reduce anastomotic leakage rate? A single institution prospective randomized study. World J Surg 2011; 35: 1367–1377.

Authors: Xiao L, Zhang W, Jiang P-C, Bu X-F, Yan Q, Li H et al.

Scientific Surgery

Rectal cancer surgery with or without bowel preparation: the French Greccar III multicentre single-blinded randomised trial. Ann Surg 2010; 252: 863–868.

Authors: Bretagnol F, Panis Y, Rullier E, Rouanet P, Berdah S, Dousset B et al. et al.

Scientific Surgery

End-to-end versus end-to-side stapled anastomosis after anterior resection for rectal cancer J Surg Oncol 2009; 99: 75-79

Authors: Brisinda G, Vanella S, Cadeddu F, Civello IM, Brandara F, Nigro C et al et al.

Scientific Surgery

Prospective randomised multi-centre trial comparing the clinical efficacy, safety and patient acceptability of circular stapled anopexy with closed diathermy haemorrhoidectomy Gut 2009; 58: 668-678

Authors: Thaha MA, Campbell KL, Kazmi SA, Irvine LA, Khalil A Binnie NR et al

Scientific Surgery

Ligasure Precise vs. conventional diathermy for Milligan-Morgan hemorrhoidectomy: a prospective, randomised, multicenter trial. Dis Colon Rectum 2008; 51: 514-519.

Authors: Altomare DF, Milito G, Andreoli R, Arcana F, Tricomi N, Salafia C et al. et al.

Scientific Surgery

Warm Sitz bath does not reduce symptoms in posthaemorrhoidectomy period: a randomised, controlled study. Aust N Z J Surg 2008; 78: 398-401.

Authors: Gupta PJ.

Scientific Surgery

The TME trial after a median follow-up of six years: local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg 2007; 246: 693-701.

Authors: Peeters KCMJ, Marijnen CAM, Nagtegaal ID, Kranenbarg EK, Putter H, Wiggers T et al.

Scientific Surgery

Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomised multicenter trial. Ann Surg 2007; 246: 207-214.

Authors: Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R.

Scientific Surgery

Meta-analysis of short-term outcomes of randomised controlled trials of LigaSure vs conventional hemorrhoidectomy. Arch Surg 2007; 142: 1209 ¿ 18.

Authors: Tan EK, Cornish J, Darzi AW, Papagrigoriadis S, Tekkis PP.

Scientific Surgery

Phase III trial of fluorouracil-based chemotherapy regimens plus radiotherapy in postoperative adjuvant rectal cancer: GI INT 0144. J Clin Oncol 2006; 24: 3542¿3547.

Authors: Smalley SR, Benedetti JK, Williamson SK, Robertson JM, Estes NC, Maher T et al.

Scientific Surgery

Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg 2006; 93:1215-1223.

Authors: Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M for the Polish Colorectal Study Group. et al.

Scientific Surgery

Prevention of recurrence of venous ulceration: randomized controlled trial of Class 2 and Class 3 elastic compression. J Vasc Surg 2006; 44: 803¿808.

Authors: Nelson EA, Harper DR, Prescott RJ, Gibson B, Brown D, Ruckley CV. et al.

Scientific Surgery

Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006; 355: 1114-1123.

Authors: Bosset J-F, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic L et al.

Scientific Surgery

Meta-analysis of colonic reservoirs versus straight coloanal anastomosis after anterior resection. Br J Surg 2006; 93: 19-32.

Authors: Heriot AG, Tekkis PP, Constantinides V, Paraskevas P, Nichols RJ, Darzi A et al.

Scientific Surgery

Randomized clinical trial comparing multiple stab incision phlebectomy and transilluminated powered phlebectomy for varicose veins. Br J Surg 2006; 93: 169¿174.

Authors: Chetter IC, Mylankal KJ, Hughes H, Fitridge R.

Scientific Surgery

Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 2004; 351: 1731-1740.

Authors: Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R et al.

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