Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury. A double-blind, placebo-controlled, randomized clinical trial. JAMA Surg 2020; 156: 11-20.

Authors: Guyette FX, Brown JB, Zenati MS, Early-Young BJ, Adams PW, Eastridge BJ et al.

Scientific Surgery

Effect of prophylactic embolization on patients with blunt trauma at high risk of splenectomy. A Randomized Clinical Trial. JAMA Surg 2020; 155: 1102-1111.

Authors: Arvieux C, Frandon J, Tidadini F, Monnin-Bares V, Foote A, Dubuisson V et al.

Scientific Surgery

A novel immune modulator for patients with necrotizing soft tissue infections (NSTI). Results of a multicenter, phase 3 randomized controlled trial of Reltecimod (AB 103). Ann Surg 2020; 272: 469-478.

Authors: Bulger E, May K, Robinson BR, Evans DC, Henry S, Green J et al.

Scientific Surgery

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomized, placebo-controlled trial. Lancet 2019; 394: 1713-1723

Authors: The CRASH-3 Trial Collaborators

Scientific Surgery

Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial. Lancet 2018; 392: 283-291.

Authors: Moore HB, Moore EE, Chapman MP, McVaney K, Silliman CC, Banerjee A et al.

Scientific Surgery

Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock. N Engl J Med 2018; 379: 315-326.

Authors: Sperry JS, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ et al.

Scientific Surgery

Effect of abdominal ultrasound on clinical care, outcomes, and resource use among children with blunt torso trauma. A randomized clinical trial. JAMA 2017; 317: 2290-2296.

Authors: Holmes JF, Kelley KM, Wootton-Gorges SL, Utter GH, Abramson LP, Rose JS et al.

Scientific Surgery

Randomized controlled trial evaluating the efficacy of peritoneal resuscitation in the management of trauma patients undergoing damage control surgery. J Am Coll Surg 2017; 224: 396–404.

Authors: Smith JW, Matheson PJ, Franklin GA, Harbrecht BG, Richardson DJ, Garrison RN et al.

Scientific Surgery

Immediate total-body CT scanning versus conventional imaging and selective CT scanning in patients with severe trauma (REACT-2): a randomised controlled trial. Lancet 2016; 388: 673-683.

Authors: Sierink JC, Treskes K, Edwards MJR, Beuker BJA, den Hartog D, Hohmann J et al.

Scientific Surgery

Transfusion of cryopreserved packed red blood cells is safe and effective after trauma: a prospective randomized trial. Ann Surg 2015; 262: 426–433.

Authors: Schreiber M, McCully B, Holcomb JB, Robinson BR, Minei JP, Stewart R et al. et al.

Scientific Surgery

Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma. The PROPPR randomized clinical trial. JAMA 2015; 313: 471-482.

Authors: Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM et al. et al.

Scientific Surgery

Whole body computed tomographic scanning leads to better survival as opposed to selective scanning in trauma patients: a systematic review and meta-analysis. J Trauma Acute Care Surg 2014; 77: 534-539.

Authors: Caputo ND, Stahmer C, Lim G, Shah K

Scientific Surgery

Results of a prospective randomized controlled study of the use of carboxymethylcellulose sodium hyaluronate adhesion barrier in trauma open abdomens. Surgery 2014; 156: 419-430.

Authors: Stawicki SP, Green JM, Martin ND, Green RH, Cipolla J, Seamon MJ et al. et al.

Scientific Surgery

Saline versus Plasma-lyte in initial resuscitation of trauma patients: a randomized trial. Ann Surg 2014; 259: 255-262.

Authors: Young JB, Utter GH, Schermer CR, Galante J, Phan HH, Yang Y et al. et al.

Scientific Surgery

Safety and efficacy of pharmacologic thromboprophylaxis following blunt head injury: a systematic review. J Trauma Acute Care Surg 2013; 75: 642–656.

Authors: Reeves F, Batty L, Pitt V, Chau M, Pattuwage L, Gruen RL et al.

Scientific Surgery

A randomized controlled pilot trial of modified whole blood versus component therapy in severely injured patients requiring large volume transfusions. Ann Surg 2013; 285: 527–533.

Authors: Cotton BA, Podbielski J, Camp E, Welch T, del Junco D, Bai Y et al. et al.

Scientific Surgery

Long-term propranolol use in severely burned pediatric patients: a randomised controlled study. Ann Surg 2012; 256: 402-411.

Authors: Herndon DN, Rodriguez NA, Diaz E, Hedge S, Jennings K, Mlcak RP et al.

Scientific Surgery

Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ 2012; 345: e5839.

Authors: Roberts I, Perel P, Prieto-Merino D, Shakur H, Coats T, Hunt BJ et al. et al.

Scientific Surgery

Five-year outcomes after oxandrolone administration in severely burned children: a randomised clinical trial of safety and efficacy. J Am Coll Surg 2012; 214: 489–502.

Authors: Porro LJ, Herndon DN, Rodriguez NA, Jennings K, Klein GL, Micak RP et al.

Scientific Surgery

Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial. BMJ 2011; 343: d3795.

Authors: CRASH 2 Collaborators (Intracranial Bleeding Study).

Scientific Surgery

Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomised, placebo controlled trial. Ann Surg 2011; 253: 431–441.

Authors: Bulger EM, May S, Kerby JD, Emerson S, Stiell IG, Schreiber MA et al.

Scientific Surgery

Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA 2011; 305: 1201–1209.

Authors: Roquilly A, Mahe PJ, Seguin P, Guitton C, Floch H, Tellier AC et al.

Scientific Surgery

Prehospital rapid sequence intubation improves functional outcome for patients with severe traumatic brain injury: a randomized controlled trial. Ann Surg 2010; 252: 959-965.

Authors: Bernard S, Nguyen V, Cameron P, Masci K, Fitzgerald M, Cooper DJ et al. et al.

Scientific Surgery

Results of the CONTROL Trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic haemorrhage. J Trauma 2010; 69: 489-500.

Authors: Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB et al.

Scientific Surgery

Prospective randomized trial of accelerated re-epithelization of skin graft donor sites using extracorporeal shock wave therapy. J Am Coll Surg 2010; 211: 361–367.

Authors: Ottomann C, Hartmann B, Tyler J, Maier H, Thiele R, Schaden W et al.

Scientific Surgery

Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg 2008; 143: 139-148.

Authors: Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, Cooper C et al.

Scientific Surgery

Prospective randomized control trial of intermittent versus continuous gastric feeds for critically ill trauma patients. J Trauma 2007; 63: 57-61.

Authors: McLeod JB, Lefton J, Houghton D, Roland C, Doherty J, Cohn SM et al.

Scientific Surgery

Effectiveness of negative pressure closure in the integration of split thickness skin grafts: a randomized, double-masked, controlled trial. Ann Surg 2006; 244: 700-705.

Authors: Llanos S, Danilla S, Barraza C, Armijo E, Pineros JL, Quintas M et al.

Scientific Surgery

Splanchnic hypoperfusion-directed therapies in trauma: a prospective, randomized trial. Am Surg 2005; 3: 252-260.

Authors: Miami Trauma Clinical Trial Group.

Scientific Surgery

Effect of intravenous corticosteroids on death within 14 days in 10 008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 2004; 364: 1321-1328.

Authors: CRASH trial collaborators

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