Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Efficacy and safety of nonantibiotic outpatient treatment in mild acute diverticulitis (DINAMO-study). A multicentre, randomised, open-label, noninferiority trial. Results from a multicenter randomized controlled trial (HOPE ECD-DBD). Ann Surg 2021; 274: e435-e442.

Authors: Mora-López L, Ruiz-Edo N, Estrada-Ferrer O, Piñana-Campón ML, Labró-Ciurans M, Escuder-Perez J et al.

Scientific Surgery

Comparing laparoscopic elective sigmoid resection with conservative treatment in improving quality of life of patients with diverticulitis. The Laparoscopic Elective Sigmoid Resection Following Diverticulitis (LASER) randomized clinical trial. JAMA Surg 2021; 156: 129-136.

Authors: Santos A, Mentula P, Pinta T, Ismael S, Rautio T, Juusela R et al.

Scientific Surgery

Laparoscopic lavage vs primary resection for acute perforated diverticulitis. Long-term outcomes from the Scandinavian Diverticulitis (SCANDIV) randomized clinical trial. JAMA Surg 2021; 156: 121-127.

Authors: Azhar N, Johanssen A, Sundstrom T, Folkesson J, Wallon C, Korner H et al.

Scientific Surgery

Prospectively randomized controlled trial on damage control surgery for perforated diverticulitis with generalized peritonitis. World J Surg 2020; 44: 4098-4105.

Authors: Kafka-Ritsch R, Zitt M, Perathoner A, Gasser E, Kaufman C, Czipin S et al.

Scientific Surgery

Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADE-DB trial): a double-blind randomised study. Lancet Gastroenterol Hepatol 2020; 5: 343-351.

Authors: Wang P, Liu X, Berzin TM, Glissen Brown JR, Liu P, Zhou C et al.

Scientific Surgery

Emergency surgery in acute diverticulitis: a systematic review. Dis Colon Rectum 2020; 63: 397-405.

Authors: Beyer-Berjot L, Maggiori L, Loiseau D, Korwin J-D, Bongiovanni J-P, Lesprit P et al.

Scientific Surgery

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch Syndrome), a 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double blind, randomised, placebo-controlled trial. Lancet 2020; 395: 1855-1863.

Authors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin J-P et al.

Scientific Surgery

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. Lancet Gastroenterol Hepatol 2020; 5: 142-151

Authors: Cornish AJ, Law PJ, Tomofeeva M, Palin K, Farrington SM, Palles C et al.

Scientific Surgery

Hartmann’s procedure versus sigmoidectomy with primary anastomosis for sigmoid diverticulitis with purulent or faecal peritonitis (LADIES): a multicenter, parallel-group, open label superiority trial. Lancet Gastroenterol Hepatol 2019; 4: 599-610

Authors: Lambrichts DPV, Vennix S , Musters GD , Mulder IM , Swank HA , Hoofwijk AGM et al.

Scientific Surgery

Long-term outcome of surgery versus conservative management for recurrent and ongoing complaints after an episode of diverticulitis. 5-year follow-up results of a multicenter randomized controlled trial (DIRECT-Trial). Ann Surg 2019; 269: 612-620.

Authors: Bolkenstein HE, Consten ECJ, van der Palen J, van de Wall BJ, Broeders IA, Bemelman WA et al.

Scientific Surgery

Operative strategies for perforated diverticulitis. A systematic review and meta-analysis. Dis Colon Rectum 2018; 61: 1442-1453.

Authors: Acuna SA, Wood T, Chesney TR, Dossa F, Wexner SDS, Quereshy F et al.

Scientific Surgery

Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis. A randomized clinical trial. JAMA 2019; 321: 156-164.

Authors: Costello SP, Hughes PA, Waters O, Bryant RB, Vincent AD, Blatchford P et al.

Scientific Surgery

Faecal microbiota transplantation alters gut microbiota in patients with irritable bowel syndrome: results from a randomised, double-blind placebo-controlled study. Gut 2018; 67: 2107–2115.

Authors: Halkjær SI, Christensen AH, Lo BZS, Browne PD, Günther S, Hansen LH et al.

Scientific Surgery

The role of antibiotics in acute uncomplicated diverticulitis: A systematic review and meta-analysis. Am J Surg 2018; 216: 604–609.

Authors: Mocanu V, Dang JT, Switzer N, Tavakoli I, Tian C, de Gara C et al.

Scientific Surgery

Efficacy and safety of sodium picosulfate/magnesium citrate for bowel preparation in a physically disabled outpatient population: a randomized, endoscopist-blinded comparison with ascorbic acid-enriched polyethylene glycol solution plus bisacodyl (The PICO-MOVI Study). Dis Colon Rectum 2018; 61: 239-249.

Authors: Mathus-Vliegen E, van der Vliet K, Wignand-van der Storm IJ, Stadwijk J

Scientific Surgery

Tranexamic acid for lower GI hemorrhage: a randomized placebo-controlled clinical trial. Dis Colon Rectum 2018; 61: 99-106.

Authors: Smith S, Murray D, Pockney P, Bendinelli C, Draganic B, Carroll R et al.

Scientific Surgery

Hartmann’s procedure or primary anastomosis for generalized peritonitis due to perforated diverticulitis: a prospective multicenter randomized trial (DIVERTI). J Am Coll Surg 2017; 225: 798-805.

Authors: Bridoux V, Regimbeau JM, Ouassi M, Mathonnet M, Mauvais F, Houivet E et al.

Scientific Surgery

Laparoscopic lavage versus primary resection for acute perforated diverticulitis: review and meta-analysis. Ann Surg 2018; 267: 252-258.

Authors: Penna M, Markar SR, Mackenzie H, Hompes R, Cunningham C

Scientific Surgery

Comparative evaluation of the efficacy of polyethylene glycol with ascorbic acid and an oral sulfate solution in a split method for bowel preparation: a randomized, multicenter phase III clinical trial. Dis Colon Rectum 2017; 60: 426-432.

Authors: Bun K, Lee SD, Han KS, Kim BC, Youk E-G, Nam MJ et al.

Scientific Surgery

Split-dose preparation for colonoscopy increases adenoma detection rate: a randomised controlled trial in an organised screening programme. Gut 2017; 66: 270-277.

Authors: Paggi S, Hassan C, Senore C, Fasoli R, Anderloni A, Buffoli F et al.

Scientific Surgery

Telemedicine for management of inflammatory bowel disease (myIBDcoach): a pragmatic, multicentre, randomized controlled trial. Lancet 2017; 390: 959–968.

Authors: de Jong MJ, van der Meulen-de Jong AE, Romberg-Camps MJ, Becx MC, Maljaars JP, Cilissen M et al.

Scientific Surgery

Laparoscopic lavage in the management of Hinchey Grade III diverticulitis: a Systematic review. Ann Surg 2017; 265: 670-676.

Authors: Marshall J, Buchwald P, Gandhi J, Schultz JK, Hider PN, Frizelle F et al.

Scientific Surgery

Celecoxib for the prevention of colorectal adenomas: results of a suspended randomized controlled trial. J Natl Cancer Inst 2016; 108: djw151.

Authors: Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F et al.

Scientific Surgery

Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia. BMJ 2016; 355: i6188.

Authors: Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ et al.

Scientific Surgery

Surgery versus conservative treatment for recurrent and ongoing left-sided diverticulitis (DIRECT Trial): an open-label, multicentre, randomised controlled trial. Lancet Gastroenterol Hepatol 2017; 2: 13-22.

Authors: Van de Wall BJM, Stam MAW, Draaisma WA, Stellato R, Bemelman WA, Boermeester MA et al.

Scientific Surgery

Laparoscopic lavage is feasible and safe for the treatment of perforated diverticulitis with purulent peritonitis: the first results from the randomized controlled trial DILALA. Ann Surg 2016; 263: 117-122.

Authors: Angenete E, Thornell A, Burcharth J, Pommergaard H-C, Skullman S, Bisgaard T et al. et al.

Scientific Surgery

Frozen vs fresh fecal microbiota transplantation and clinical resolution of diarrhea in patients with recurrent Clostridium difficile infection. A randomized clinical trial. JAMA 2016; 315: 142-149.

Authors: Lee CH, Steiner T, Petrof EO, Smieja M, Roscoe D, Nematallah A et al. et al.

Scientific Surgery

Real-time optical diagnosis for diminutive colorectal polyps using narrow-band imaging: the VALID randomised clinical trial. Gut 2015; 64: 1569-1577.

Authors: Kaltenbach T, Rastogi A, Rouse RV, McQuaid KR, Sato T, Bansal A et al. et al.

Scientific Surgery

Aspirin use after diagnosis but not prediagnosis improves established colorectal cancer survival: a meta-analysis. Gut 2015; 64: 1419-1425.

Authors: Li P, Wu H, Zhang H, Shi Y, Xu J, Ye Y et al. et al.

Scientific Surgery

Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial. Lancet 2015; 386:1269–1277.

Authors: Vennix S, Muster GD, Mulder IM, Swank HA, Consten EC, Belgers EH et al on behalf of the Ladies trial collaborators et al.

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