Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Systematic review and meta-analysis of clinical trials examining the benefit of exercise programmes using Nordic Walking in patients with peripheral artery disease. Eur J Vasc Endovasc Surg 2018; 56: 534–543.

Authors: Golledge J, Maarij K, Moxon JV, Beard JD, Girold S, Wrang H et al.

Scientific Surgery

A polymer-coated, paclitaxel eluting stent (Eluvia) versus a polymer-free, paclitaxel-coated stent (Zilver PTX) for endovascular femoropopliteal intervention (IMPERIAL): a randomized non-inferiority trial. Lancet 2018; 392: 1541-1551.

Authors: Gray WA, Keirse K, Soga Y, Benko A, Babaev A, Yokoi Y et al.

Scientific Surgery

No clinical benefit of intramuscular delivery of bone marrow-derived mononuclear cells in nonreconstructable peripheral arterial disease: results of a phase-III randomized-controlled trial. Ann Surg 2018; 268: 756-761.

Authors: Lindeman J, Zwaginga J, Kallenberg-Lantrua G, van Wissen RC, Schepers A, van Bockel HJ et al.

Scientific Surgery

Closed incision negative pressure therapy reduces surgical site infections in vascular surgery: a prospective randomised trial (AIMS Trial). Eur J Vasc Endovasc Surg 2018; 56: 442-448.

Authors: Gombert A, Babilon M, Barbati ME, Keszei A, von Trotha KT, Jalaie H et al.

Scientific Surgery

A systematic review of the efficacy of aspirin monotherapy versus other antiplatelet therapy regimens in peripheral arterial disease. J Vasc Surg 2018; 67: 1922-1932.

Authors: Beiswenger AC, Jo A, Harth K, Kumins NH, Shishehbor MH, Kashyap VS et al.

Scientific Surgery

Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med 2018; 379: 215-225.

Authors: Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ et al.

Scientific Surgery

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials. Lancet 2018; 392: 387–399.

Authors: Rothwell PM, Cook NR, Gaziano JM, Price JF, Belch JFF, Roncaglioni MC et al.

Scientific Surgery

Infrapopliteal angioplasty of one or more than one artery for critical limb ischaemia: a randomised clinical trial. Eur J Vasc Endovasc Surg 2018; 55: 518-527.

Authors: Biagioni RB, Biagioni LC, Nasser F, Burihan MC, Ingrund JC, Neser A et al.

Scientific Surgery

Systematic review and meta-analysis of high-pressure intermittent limb compression for the treatment of intermittent claudication. J Vasc Surg 2018; 67: 620–628.e2.

Authors: Oresanya L, Mazzei M, Bashir R, Farooqui A, Athappan G, Roth S et al.

Scientific Surgery

A feasibility double-blind randomized placebo-controlled trial of extracorporeal shockwave therapy as a novel treatment for intermittent claudication. J Vasc Surg 2018; 67: 514–521.e2.

Authors: Harwood AE, Green J, Cayton T, Raza A, Wallace T, Carradice D et al.

Scientific Surgery

Effect of a home-based exercise intervention of wearable technology and telephone coaching on walking performance in peripheral artery disease. The HONOR randomized clinical trial. JAMA 2018; 319: 1665-1676.

Authors: McDermott MM, Spring B, Berger S, Treat-Jacobson D, Conte MS, Creager MA et al.

Scientific Surgery

Outcomes after angiography with sodium bicarbonate and acetylcysteine. N Engl J Med 2018; 378: 603-614.

Authors: Weisbord SD, Gallagher M, Jneid H, Garcia S, Cass A, Thwin S-S et al.

Scientific Surgery

Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet 2018; 391: 219-229.

Authors: Anand S, Bosch J, Eikelboom JW, Connolly SJ, Diaz R, Widimsky P et al.

Scientific Surgery

Randomized clinical trial of negative pressure wound therapy for high-risk groin wounds in lower extremity revascularization . J Vasc Surg 2017; 66: 1814-1819.

Authors: Lee K, Murphy PB, Ingves MV, Duncan A, DeRose G, Dubois L et al.

Scientific Surgery

Effect of granulocyte-macrophage colony-stimulating factor with or without supervised exercise on walking performance in patients with peripheral artery disease. The PROPEL randomized clinical trial. JAMA 2017; 318: 2089-2098.

Authors: McDermott MM, Ferrucci L, Tian L, Guralnik JM, Lloyd-Jones D, Kibbe MR et al.

Scientific Surgery

Hyperbaric oxygen therapy in the treatment of ischemic lower- extremity ulcers in patients with diabetes: Results of the DAMO2CLES multicenter randomized clinical trial. Diabetes Care 2018; 41: 112-119.

Authors: Santema KT, Stoekenbroek RM, Koelemay MJ, Reekers JA, van Dortmont LM, Oomen A et al.

Scientific Surgery

Efficacy and safety of aspirin in patients with peripheral vascular disease: an updated systematic review and meta-analysis of randomized controlled trials. PLoS ONE 2017; 12: e0175283.

Authors: Mahmoud AN, Elgendy AY, Rambarat C, Mahtta D, Elgendy IY, Bavry AA et al.

Scientific Surgery

Low-dose paclitaxel–coated versus uncoated percutaneous transluminal balloon angioplasty for femoropopliteal peripheral artery disease. Circulation. 2017; 135: 2227-2236.

Authors: Schroeder H, Werner M, Meyer D-R, Reimer P, Krüger K, Jaff MR et al.

Scientific Surgery

Randomized comparison of paclitaxel-eluting balloon and stenting versus plain balloon plus stenting versus directional atherectomy for femoral artery disease (ISAR-STATH). Circulation. 2017; 135: 2218-2226.

Authors: Ott I, Cassese S, Groha P, Steppich B, Hadamitzky M, Ibrahim T et al.

Scientific Surgery

Evaluation of cell therapy on exercise performance and limb perfusion in peripheral artery disease. Circulation. 2017; 135: 1417-1428.

Authors: Perin EC, Murphy MP, March KL, Bolli R, Loughran J, Yang PC et al.

Scientific Surgery

Rivaroxaban with or without aspirin in stable cardiovascular disease. N Engl J Med 2017; 377: 1319-1330.

Authors: Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O et al.

Scientific Surgery

Paclitaxel-coated balloon reduces target lesion revascularization compared with standard balloon angioplasty. J Vasc Surg 2017; 65: 558–570.

Authors: Candy N, Ng E, Velu R

Scientific Surgery

A network meta-analysis of randomized controlled trials comparing treatment modalities for de novo superficial femoral artery occlusive lesions. J Vasc Surg 2017; 65: 234–245.

Authors: Antonopoulos CN, Mylonas SN, Moulakakis KG, Sergentanis TN, Sfyroeras GS, Lazaris AM et al.

Scientific Surgery

Primary stenting of the superficial femoral artery in intermittent claudication improves health related quality of life, ABI and walking distance: 12 month results of a controlled randomised multicenter trial. Eur J Vasc Endovasc Surg 2017; 53: 686-694.

Authors: Lindgren H, Qvarfordt P, Akesson M, Bergman S, Gottsater A, Jansson I et al.

Scientific Surgery

Efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease Fontaine stage IV: results of a placebo-controlled randomized multicenter trial (ESPECIAL). Eur J Vasc Endovasc Surg 2017; 53: 559-566.

Authors: Lawall H, Pokrovsky A, Checinski P, Ratushnyuk A, Hamm G, Randerath O et al.

Scientific Surgery

Low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes mellitus. 10-year follow-up of a randomized controlled trial. Circulation. 2017; 135: 659-670.

Authors: Saito Y, Okada S, Ogawa H, Soejima H, Sakuma M, Nakayama M et al.

Scientific Surgery

Ticagrelor compared with clopidogrel in patients with prior lower extremity revascularization for peripheral artery disease. Circulation. 2017; 135: 241-250.

Authors: Schuyler Jones W, Baumgartner I, Hiatt WR, Heizer G, Conte MS, White CJ et al.

Scientific Surgery

Evacetrapib and cardiovascular outcomes in high-risk vascular disease. N Engl J Med 2017; 376: 1933-1942.

Authors: Lincoff AM, Nicholls SJ, Riesmeyer JS, Barter PJ, Brewer HB, Fox KAA et al.

Scientific Surgery

Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet 2017; 389: 1312–1322.

Authors: Nijssen EC, Rennenberg RJ , Nelemans PJ, Essers BA, Janssen MM, Vermeeren MA et al.

Scientific Surgery

Ticagrelor versus clopidogrel in symptomatic peripheral artery disease. N Engl J Med 2017; 376: 32-40.

Authors: Hiatt WR, Fowkes GR, Heizer G, Berger JS, Baumgartner I, Held P et al.

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