Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

Effect of a deep learning-based system on the miss rate of gastric neoplasms during upper gastrointestinal endoscopy: a single-centre, tandem, randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 700-708.

Authors: Wu L, Shang R, Sharma P, Zhou W, Liu J, Yao L et al.

Scientific Surgery

Short-term outcomes of robotic gastrectomy vs laparoscopic gastrectomy for patients with gastric cancer. A randomized clinical trial. JAMA Surg 2021; 156: 954-963.

Authors: Ojima T, Nakamura M, Hayata K, Kitadani J, Katsuda M, Takeuchi A et al.

Scientific Surgery

Long-term efficacy of neoadjuvant chemoradiotherapy plus surgery for the treatment of locally advanced esophageal squamous cell carcinoma. The NEOCRTEC5010 randomized clinical trial. JAMA Surg 2021; 156: 721-729.

Authors: Yang H, Liu H, Chen Y, Zhu C, Fang W, Yu Z et al.

Scientific Surgery

Intrathoracic vs cervical anastomosis after totally or hybrid minimally invasive esophagectomy for esophageal cancer. A randomized clinical trial. JAMA Surg 2021; 156: 601-610.

Authors: Van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F et al.

Scientific Surgery

IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

Authors: Lee J, Garvey EM, Bundrant N, Hargis-Villanueva A, Kang P, Osuchukwu O et al.

Scientific Surgery

Morbidity and mortality of patients who underwent minimally invasive esophagectomy after neoadjuvant chemo-radiotherapy vs neoadjuvant chemotherapy for locally advanced esophageal squamous cell carcinoma. A randomized clinical trial. JAMA Surg 2021; 156: 444-451.

Authors: Wang H, Tang H, Fang Y, Tan L, Yin J, Shen Y et al.

Scientific Surgery

A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

Authors: O’Leary DP, Walsh SM, Bolger J, Baban C, Humphreys H, O’Grady S et al.

Scientific Surgery

Five-year survival outcomes of hybrid minimally invasive esophagectomy in esophageal cancer. Results of the MIRO Randomized Clinical Trial. JAMA Surg 2021; 156: 323-332.

Authors: Nuytens F, Dabakuyo-Yonli TS, Meunier B, Gagnière J, Collet D, D’Journo XB et al.

Scientific Surgery

Palliative radiotherapy after oesophageal cancer stenting (ROCS): a multicentre, open-label, phase 3 randomised controlled trial. Lancet Gastroenterol Hepatol 2021; 6: 292-303.

Authors: Adamson DA, Byrne A, Porter C, Blazeby J, Griffiths G, Nelson A et al.

Scientific Surgery

Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss and quality of life at 7 Years in patients with morbid obesity. The SLEEVEPASS randomized clinical trial. JAMA Surg 2021; 156: 137-146.

Authors: Gronroos S, Helmio M, Juuti A, Tiusanen R, Hurme S, Loyttyniemi E et al.

Scientific Surgery

Extensive peritoneal lavage with saline after curative gastrectomy for gastric cancer (EXPEL): a multicentre randomised controlled trial. Lancet Gastro Hepatol 2021; 6: 120-127.

Authors: Kono K, Misawa K, Yabusaki H, Kinoshita T, Lau PC, Kim YW et al.

Scientific Surgery

Assessment of robotic versus laparoscopic distal gastrectomy for gastric cancer. A randomized controlled trial. Ann Surg 2021; 273: 858-867.

Authors: Lu J, Zheng C-H, Xu B-B, Xie J-W, Wang J-B, Lin J-X et al.

Scientific Surgery

Adjuvant nivolumab in resected esophageal or gastroesophageal junction cancer. N Engl J Med 2021; 384: 1191-1203.

Authors: Kelly RJ, Ajani JA, Kuzdzal J, Zander T, van Cutsem E, Piessen G et al.

Scientific Surgery

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol Hepatol 2020; 5: 900-907.

Authors: Stevens TW, Haasnoot GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ et al.

Scientific Surgery

Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis. The APPAC II randomized clinical trial. JAMA 2021; 325: 353-362.

Authors: Sipppola S, Haijanen J, Gronooos J, Rautio T, Nordstrom P, Rantanen T et al.

Scientific Surgery

Effect of gastric bypass vs best medical treatment on early-stage chronic kidney disease in patients with type 2 diabetes and obesity. A randomized clinical trial. JAMA Surg 2020; 155: e200420.

Authors: Cohen RV, Pereira TV, Aboud CM, Petry TBZ, Correa JLL, Schiavon CA et al.

Scientific Surgery

Efficacy and safety of ursodeoxycholic acid for the prevention of gallstone formation after gastrectomy in patients with gastric cancer. The PEGASUS-D randomized clinical trial. JAMA Surg 2020; 155: 703-711.

Authors: Lee SH, Jang DK, Yoo M-W, Hwang S-H, Ryu S-Y, Kwon OK et al.

Scientific Surgery

Laparoscopic sleeve gastrectomy versus laparoscopic Roux-en-Y gastric bypass. A systematic review and meta-analysis of weight loss, comorbidities, and biochemical outcomes from randomized controlled trials. Ann Surg 2021; 273: 66-74.

Authors: Lee Y, Doumouras A, Yu J, Aditya I, Gmora S, Anvari M et al.

Scientific Surgery

Banded versus nonbanded sleeve gastrectomy. A randomized controlled trial with 3 years of follow-up. Ann Surg 2020; 272: 690-695.

Authors: Fink J, Hetzenecker A, Seifert G, Runkel M, Laessle C, Fichtner-Feigl S et al.

Scientific Surgery

A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med 2020; 383: 1907-1919.

Authors: The CODA Collaborative

Scientific Surgery

Efficacy and safety of the duodeno-jejunal bypass liner in patients with metabolic syndrome. A multicenter randomized controlled trial (ENDOMETAB). Ann Surg 2020; 272: 696-702.

Authors: Caiazzo R, Branche J, Raverdy V, Czernichow S, Carette C, Robert M et al.

Scientific Surgery

Safety and efficacy of indocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer. A randomized clinical trial. JAMA Surg 2020; 155: 300-311.

Authors: Chen Q-Y, Xie J-W, Zhong Q, Wang J-B, Lin J-X, Lu J et al.

Scientific Surgery

Surgical morbidity and mortality from the multicenter randomized controlled NeoRes II Trial. Standard versus prolonged time to surgery after neoadjuvant chemoradiotherapy for esophageal cancer. Ann Surg 2020; 272: 684-689.

Authors: Nilsson K, Klevebro F, Rouvelas I, Lindblad M, Szabo E, Halldestam I et al.

Scientific Surgery

Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol 2020; 5: 658-666.

Authors: Andreson V, Gschossmann J, Layer P

Scientific Surgery

Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy vs appendectomy for uncomplicated acute appendicitis. A secondary analysis of a randomized clinical trial. JAMA Surg 2020; 155: 283-289.

Authors: Sippola S, Haijanen J, Viinikainen L, Gronroos J, Paajanen H, Rautio T et al.

Scientific Surgery

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut 2020; 69: 859–867.

Authors: El-Salhy M, Hatlebakk JG, Gilja OH, Kristoffersen AB, Hausken T

Scientific Surgery

Are postoperative intravenous antibiotics indicated after laparoscopic appendicectomy for simple appendicitis? A prospective double-blinded randomized controlled trial. Ann Surg 2020; 272: 248-252.

Authors: Mennie N, Panabokke G, Chang A, Tanny ST, Cheng W, Pacilli M et al.

Scientific Surgery

Cytosponge-trefoil factor 3 versus usual care to identify Barrett’s oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial. Lancet 2020; 396: 333-344.

Authors: Fitzgerald RC, di Pietro M, O’Donovan M, Maroni R, Muldrew B, Debiram-Beeecham I et al.

Scientific Surgery

Luglio G, Rispo A, Imperatore N, Giglio MC, Amendola A, Tropeano FP et al. Surgical prevention of anastomotic recurrence by excluding mesentery in Crohn’s Disease: the SuPREMe-CD Study – A Randomized Clinical Trial. Ann Surg 2020; 272: 210-217.

Authors: Luglio G , Rispo A, Imperatore N, Giglio MC, Amendola A, Tropeano FP et al.

Scientific Surgery

Randomized comparison of gastric tube reconstruction with and without duodenal diversion plus Roux-en-Y anastomosis after esophagectomy. Ann Surg 2020; 272: 48-54.

Authors: Yano M, Sugimura K, Miyata H, Motoori M, Tanaka K, Omori T et al.

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