Scientific Surgery Online Journals

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Scientific Surgery

IMPPACT (Intravenous Monotherapy for Postoperative Perforated Appendicitis in Children Trial). Randomized clinical trial of monotherapy versus multi-drug antibiotic therapy. Ann Surg 2021; 274: 406-410.

Authors: Lee J, Garvey EM, Bundrant N, Hargis-Villanueva A, Kang P, Osuchukwu O et al.

Scientific Surgery

A randomized clinical trial evaluating the efficacy and quality of life of antibiotic-only treatment of acute uncomplicated appendicitis. Results of the COMMA Trial. Ann Surg 2021; 274: 240-247.

Authors: O’Leary DP, Walsh SM, Bolger J, Baban C, Humphreys H, O’Grady S et al.

Scientific Surgery

Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn’s disease: retrospective long-term follow-up of the LIR!C trial. Lancet Gastroenterol Hepatol 2020; 5: 900-907.

Authors: Stevens TW, Haasnoot GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ et al.

Scientific Surgery

Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis. The APPAC II randomized clinical trial. JAMA 2021; 325: 353-362.

Authors: Sipppola S, Haijanen J, Gronooos J, Rautio T, Nordstrom P, Rantanen T et al.

Scientific Surgery

A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med 2020; 383: 1907-1919.

Authors: The CODA Collaborative

Scientific Surgery

Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. Lancet Gastroenterol Hepatol 2020; 5: 658-666.

Authors: Andreson V, Gschossmann J, Layer P

Scientific Surgery

Quality of life and patient satisfaction at 7-year follow-up of antibiotic therapy vs appendectomy for uncomplicated acute appendicitis. A secondary analysis of a randomized clinical trial. JAMA Surg 2020; 155: 283-289.

Authors: Sippola S, Haijanen J, Viinikainen L, Gronroos J, Paajanen H, Rautio T et al.

Scientific Surgery

Are postoperative intravenous antibiotics indicated after laparoscopic appendicectomy for simple appendicitis? A prospective double-blinded randomized controlled trial. Ann Surg 2020; 272: 248-252.

Authors: Mennie N, Panabokke G, Chang A, Tanny ST, Cheng W, Pacilli M et al.

Scientific Surgery

Non-operative treatment versus appendectomy for acute non-perforated appendicitis in children: five-year follow up of a randomized controlled pilot trial. Ann Surg 2020; 271: 1030-1035.

Authors: Patkova B, Svenningsson A, Almström M, Eaton S, Wester T, Svensson JF et al.

Scientific Surgery

Efficacy of soluble fibre, antispasmodic drugs and gut-brain neuromodulators in irritable bowel syndrome: a systematic review and network meta-analysis. Lancet Gastroenterol Hepatol 2020; 5: 117-131.

Authors: Black CJ, Yuan Y , Selinger CP, Camilleri CP, Quigley EMM, Moayyedi P et al.

Scientific Surgery

Povidone-iodine irrigation for pediatric perforated appendicitis may be protective. A Bayesian pilot randomized controlled trial. Ann Surg 2020; 271: 827-833

Authors: Anderson KT, Putnam LR, Bartz-Kurycki MA, Hamilton EC, Yafi M, Pedroza C et al.

Scientific Surgery

Antibiotic treatment and appendectomy for uncomplicated acute appendicitis in adults and children. A systematic review and meta-analysis. Ann Surg 2019; 270: 1028-1040

Authors: Podda M, Gerardi C, Cillara N, Fearnhead N, Gomes CA, Birindelli A et al.

Scientific Surgery

Risk of appendiceal neoplasm in periappendicular abscess in patients treated with interval appendectomy vs follow-up with magnetic resonance imaging. 1-year outcomes of the Peri–appendicitis Acuta randomized clinical trial. JAMA Surg 2019; 154: 200-207.

Authors: Mällinen J, Rautio T, Grönroos J, Rantanen T, Nordström P, Savolainen H et al.

Scientific Surgery

A randomized double blinded study to determine the effectiveness of utilizing intraperitoneal bupivacaine: does it reduce postoperative opioid use following laparoscopic appendectomy? Am J Surg 2019; 217: 479-482.

Authors: Sevensma K, Schleichert T, Shwickerath C, Shoemaker A, Miller C

Scientific Surgery

Efficacy of preoperative oral antibiotic prophylaxis for the prevention of surgical site infections in patients with Crohn’s Disease. A Randomized Controlled Trial. Ann Surg 2019; 269: 420-426.

Authors: Uchino M, Ikeuchi H, Bando T, Chohno T, Sasaki H, Horio Y et al.

Scientific Surgery

Five-year follow-up of antibiotic therapy for uncomplicated acute appendicitis in the APPAC randomized clinical trial. JAMA 2018; 320: 1259-1265.

Authors: Salminen P, Hannu Paajanen T, Rautio T, Nordström P, Aarnio M, Rantanen T et al.

Scientific Surgery

Comparison of superficial surgical site infection between delayed primary versus primary wound closure in complicated appendicitis: a randomized controlled trial. Ann Surg 2018; 267: 631-637.

Authors: Siribumrungwong B, Chantip A, Noorit P, Wilasrusmee C, Ungpinitpong W, Chotiya P et al.

Scientific Surgery

Optimal stump management in laparoscopic appendectomy: a network meta-analysis by the Minimally Invasive Surgery Synthesis of Interventions and Outcomes Network. Surgery 2017: 162: 994-1005.

Authors: Antoniou SA, Mavridis D, Hajibandeh S, Antoniou GA, Gorter R, Tenhagen M et al.

Scientific Surgery

Effect of tight control management on Crohn’s disease (CALM): a multicentre, randomised, controlled phase 3 trial. Lancet 2017; 390: 2779-2789.

Authors: Colombel J-F, Panaccione R, Bossuyt P, Lukas M, Baert F, Vaňásek T et al.

Scientific Surgery

Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015: CRD42015016882). Ann Surg 2017; 265: 889-900.

Authors: Harnoss J, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss J et al.

Scientific Surgery

Appendectomy skin closure technique, randomized controlled trial: changing paradigms (ASC). World J Surg 2016; 40: 2603–2610.

Authors: Andrade LAM, Munoz FYP, Baez MVJ, Collazos SS, Ferretiz MAM, Ruiz B et al.

Scientific Surgery

Antibiotics versus appendicectomy for the treatment of uncomplicated acute appendicitis: an updated meta-analysis of randomised controlled trials. World J Surg 2016; 40: 2305–2318.

Authors: Rollins K, Varadhan KK, Neal KR, Lobo DN

Scientific Surgery

A mechanistic multicentre, parallel group randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D). Gut 2016; 65: 91-99.

Authors: Lam C, Tan W, Leighton M, Hastings M, Lingaya M, Falcone Y et al.

Scientific Surgery

Randomised controlled trial of mesalazine in IBS. Gut 2016; 65: 82-90.

Authors: Giovanni B, Cremon C, Annese V, Basilisco G, Bazzoli M, et al. et al.

Scientific Surgery

Saline vs tissue plasminogen activator irrigations after drain placement for appendicitis-associated abscess: a prospective randomized trial. J Am Coll Surg 2015; 221: 390–396.

Authors: St Peter SD, Shah SR, Adibe OO, Sharp SW, Reading B, Cully B et al. et al.

Scientific Surgery

Laparoscopic surgery or conservative treatment for appendiceal abscess in adults? A randomized controlled trial. Ann Surg 2015; 262: 237–242.

Authors: Mentula P, Sammalkorpi H, Leppäniemi A

Scientific Surgery

Antibiotic therapy vs appendectomy for treatment of uncomplicated acute appendicitis. The APPAC randomized clinical trial. JAMA. 2015; 313: 2340-2348.

Authors: Salminen P, Paajanen H, Rautio T, Nordström P, Aarnio M, Rantanen T et al. et al.

Scientific Surgery

Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children: a pilot randomized controlled trial. Ann Surg 2015; 261: 67-71.

Authors: Svensson J, Patkova B, Almström M, Naji H, Hall NJ, Eaton S et al. et al.

Scientific Surgery

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea. Gut 2014; 63: 1617-1625.

Authors: Garsed K, Chernova J, Hastings M, Lam C, Marciani L, Singh G et al. et al.

Scientific Surgery

Meta-analysis of randomized trials on single incision laparoscopic versus conventional laparoscopic appendectomy. Am J Surg 2014; 207: 613-622.

Authors: Antoniou SA, Koch OO, Antoniou GA, Lasithiotakis K, Chalkiadakis GE, Pointer R et al. et al.

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